Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase

Townsend, Duane E.; Rs, Sparkes; Baluda, Maryellen C.; McClelland, G. A. H.

doi:10.1016/s0002-9378(15)30365-3

Cited by 202 publications

(89 citation statements)

References 11 publications

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“…After screening patients for G6PD heterozygosity by analysis of red blood cells, the resected fibroids and myometrium were analyzed for the presence of one or both electrophoretic types of G6PD. In two studies (Linder and Gartler 1965;Townsend et al 1970), both G6PD types (A and B) were identified in almost all samples of myometrium, whereas only one G6PD type (A or B) was identified in each of the leiomyomas. Furthermore, both A and B tumors were often identified in the same patient, indicating independent origins of the individual fibroids.…”

Section: The Genetic Findingsmentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

497

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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Section: The Genetic Findingsmentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

497

392

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“…Some data, however, indicate that leiomyomas originate from a single neoplastic stem cell of the smooth muscle tissue of the myometrium [4]. Although the exact factors triggering myomatous neoplasia are unknown, oestrogens, progestins and growth factors [epidermal growth factor (EGF) and insulin-like growth factor (IGF)] all appear to play a role in the growth of fibroids.…”

Section: Aetiology and Pathologymentioning

confidence: 99%

Submucous myomas: diagnosis and therapy

et al. 2007

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In this review problems concerning diagnosis and therapy of submucous myomas are discussed. In abnormal blood loss, especially during menstrual periods, it is probable that the submucous locations of fibroids have the strongest relationship with the symptoms. Both in diagnostic and therapeutic possibilities, in the past decennium, a wide range of fine tuning has been developed that has changed dramatically the optimal management of submucous myomas and, therefore, of bleeding abnormalities during premenopause. Over-treatment can thus be prevented: for instance, hysterectomy in menorrhagia caused by a small pedunculated submucous fibroid. New modalities of minimally invasive treatment, however, have specific intrinsic problems that justify the development of protocols for these techniques. For the diagnosis of submucous myoma, and preceding operative treatment, intrauterine diagnosis through ultrasound or hysteroscopic imaging is mandatory. Hysteroscopic treatment of submucous myomas is the method of preference, unless the abnormality is too large or too numerous. Various practical aspects of treatment are discussed. Surgery for abnormalities that are not included in the basic training package according to Goals for the education of gynaecologists, ought to be performed by a gynaecologist with additional training and experience.

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“…On the basis of biochemical and cytogenetic studies every leiomyoma is thought to represent a product of clonal expansion of an individual myocyte [1][2][3]. Just as it is the case with other tumours, probably several genetically sensitive sites exist, which lead to dysregulation of a smooth muscle cell, resulting in its transformation to the common phenotype of a leiomyoma cell.…”

Section: Introductionmentioning

confidence: 99%

The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age.

Plewka

Madej²,

Plewka³

et al. 2010

Folia Histochem Cytobiol.

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Uterine myomas represent one of the most common female diseases. Uterine myomas or fibromas are benign, hormone-responding tumours of, respectively, smooth muscles and fibroblasts and their aetiology induces a significant interest. In myomas the presence of aromatase was detected and, in addition, oestrogen was found to be synthesized in myoma cells. The studies were performed on myoma patients of generative age and those in peri-menopausal age. Expression of TRAF2 and TRAF6 proteins was examined using immunohistochemistry and Western blot approach in small and large uterine myomas isolated from women of various age. In addition, the evaluation was conducted at the periphery of every myoma. We indicated that the level of both tested proteins in myomas is higher than in control. TRAF2 level in myometrium was lower than in myomas but higher than in control. In the case of TRAF6 those changes were ambiguous. Age didn't have influence the level of expression in both tested TRAF in studied structures.

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Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase

Cited by 202 publications

References 11 publications

Etiology and pathogenesis of uterine leiomyomas: a review.

Etiology and pathogenesis of uterine leiomyomas: a review.

Submucous myomas: diagnosis and therapy

The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age.

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