We compute the isospin-asymmetry dependence of microscopic optical model potentials from realistic chiral two-and three-body interactions over a range of resolution scales Λ 400 − 500 MeV. We show that at moderate projectile energies, Einv = 110 − 200 MeV, the real isovector part of the optical potential changes sign, a phenomenon referred to as isospin inversion. We also extract the strength and energy dependence of the imaginary isovector optical potential and find no evidence for an analogous phenomenon over the range of energies, E ≤ 200 MeV, considered in the present work. Finally, we compute for the first time the leading corrections to the Lane parametrization for the isospin-asymmetry dependence of the optical potential and observe an enhanced importance at low scattering energies.Introduction -The structure and dynamics of neutronrich nuclei are key inputs for modeling neutron stars, core-collapse supernovae and r-process nucleosynthesis [1][2][3][4][5][6][7][8]. Elucidating the properties of highly isospinasymmetric nuclear matter is therefore a priority in lowenergy nuclear science research and a major motivation for the development of next-generation radioactive ion beam (RIB) facilities. Microscopic many-body methods [9-11] with chiral two-and three-body forces have been successful in describing the bound-state properties of neutron-rich matter. Complementary and consistent nuclear reaction models are under development [12][13][14], and of these, global optical potentials aim to address the broadest theory needs for interpreting RIB scattering experiments and simulating r-process nucleosynthesis. In fact, current modeling of the strong r-process favors a cold scenario in binary neutron star mergers [6][7][8][15][16][17], where mass transfer to highly neutron-rich isotopes occurs and freeze-out is achieved more rapidly, which enhances the importance of radiative neutron capture processes in determining the final abundance pattern of rprocess elements [18].