Unilateral fungal keratitis after small-incision lenticule extraction

Sachdev, Gitansha Shreyas; Diwan, Shilpi; Sachdev, Mahipal S

doi:10.1016/j.jcro.2018.08.003

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…We have reviewed the literature and found a total of ten patients reported to have had post-SMILE IK [3][4][5][6][7][8][9]. Table 1 summarizes the case reports of post-SMILE IK.…”

Section: Discussionmentioning

confidence: 99%

“…Small incision lenticule extraction (SMILE) is a relatively new flapless procedure that take benefit from femtosecond laser to cut a precise intrastromal lenticule, which is then extracted via a small keyhole incision [2]. Only few cases of IK post-SMILE have been reported [3][4][5][6][7][8][9]. We report an unusual severe unilateral fungal keratitis post-SMILE.…”

Section: Introductionmentioning

confidence: 99%

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Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

Soleimani

Haydar

2021

J Ophthal Inflamm Infect

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Purpose To report a case of perforated fungal keratitis after small incision lenticule extraction (SMILE) treated with penetrating keratoplasty (PKP). Methods Case report and literature review. Results A 41-year-old woman presented with culture-proven unilateral fungal keratitis 4 days after uneventful SMILE. Her visual acuity was hand motion. The patient was treated with voriconazole irrigation (50 μm/0.1 ml) of the pocket and intrastromal voriconazole injection, in addition to systemic and topical antifungals. Despite aggressive management and decreased infiltration, the cornea was perforated and subsequently treated with PKP. Conclusions Infectious keratitis after SMILE is unusual. To our knowledge, this is the first report of perforated fungal keratitis post-SMILE. PKP eradicated the infection.

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“…We have reviewed the literature and found a total of ten patients reported to have had post-SMILE IK [3][4][5][6][7][8][9]. Table 1 summarizes the case reports of post-SMILE IK.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

Soleimani

Haydar

2021

J Ophthal Inflamm Infect

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“…These cases include 68 cases of Staphylococcus aureus, 23 cases of Coagulasenegative Staphylococcus (CNS), 62 cases of Mycobacterium and 14 case of Aspergillus. Currently, only around 17 cases of infectious keratitis post-SMILE have been reported internationally [39][40][42][43][44][45][46][47][48] . Among these cases, ten are bacterial infections (including Staphylococcus aureus, Streptococcus pneumoniae, hemolytic Streptococcus, Mycobacterium tuberculosis, and bacterial keratitis without culture confirmation), two are unilateral fungal infections [45,48] , and one is caused by unilateral herpes simplex virus [47] .…”

Section: Infectious Keratitis After Laser Vision Correctionmentioning

confidence: 99%

“…Currently, only around 17 cases of infectious keratitis post-SMILE have been reported internationally [39][40][42][43][44][45][46][47][48] . Among these cases, ten are bacterial infections (including Staphylococcus aureus, Streptococcus pneumoniae, hemolytic Streptococcus, Mycobacterium tuberculosis, and bacterial keratitis without culture confirmation), two are unilateral fungal infections [45,48] , and one is caused by unilateral herpes simplex virus [47] . Except for one case of non-tuberculous mycobacterial infection [44] , all cases exhibit clinical signs of corneal infection within 7d after the surgery.…”

Section: Infectious Keratitis After Laser Vision Correctionmentioning

confidence: 99%

Research progress on animal models of corneal epithelial-stromal injury

Liu,

Sheng,

et al. 2023

Int J Ophthalmol

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A corneal epithelial-stromal defect is recognized as a major contributor to corneal scarring. Given the rising prevalence of blindness caused by corneal scarring, increasing attention has been focused on corneal epithelial-stromal defects. Currently, the etiology and pathogenesis of these defects remain inadequately understood, necessitating further investigation through experimental research. Various modeling methods exist both domestically and internationally, each with distinct adaptive conditions, advantages, and disadvantages. This review primarily aims to summarize the techniques used to establish optimal animal models of corneal epithelial-stromal injury, including mechanical modeling, chemical alkali burns, post-refractive surgery infections, and genetic engineering. The intention is to provide valuable insights for studying the mechanisms underlying corneal epithelial-stromal injury and the development of corresponding therapeutic interventions.

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“…We identified 5 reports of culture-proven infectious keratitis after SMILE in the literature, including a case of Streptococcus pneumonia, Staphylococcus haemolyticus and warneri, Staphylococcus aureus, Aspergillus species, and Mycobacterium abscessus (Table 1). [2][3][4][5][6] We describe the first case of M. chelonae keratitis and first case of late-onset (.2 wk) cultureproven infectious keratitis after SMILE and its management with topical, systemic, and intrastromal antibiotics, interface irrigation, and cap amputation.…”

mentioning

confidence: 99%

Late-Onset Nontuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction

Wan

Lam

et al. 2021

Cornea

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The purpose of this article was to report a case of unilateral late-onset nontuberculous mycobacterial keratitis after small incision lenticule extraction (SMILE).Methods: This was a case report.Results: A 27-year-old woman presented with Mycobacterium chelonae keratitis 3 weeks after uncomplicated SMILE with a solitary interface infiltrate. The keratitis worsened after an initial response to topical fortified and interface antibiotic irrigation. Despite repeated interface irrigation and topical and oral antibiotics, progressive, diffuse stromal infiltrates followed by melting of the cap ensued over the next 6 weeks. Cap amputation and intrastromal antibiotic injection followed by prolonged topical and oral antibiotics usage for the following 5 weeks led to infiltrate resolution and re-epithelization of the residual stromal bed. All medications were tapered off over 6 months after initial presentation without recurrence, but anterior stromal scarring and corneal neovascularization persisted. Conclusions: Cap amputation and intrastromal antibiotic injectionfor intractable post-SMILE keratitis can prevent the need for therapeutic keratoplasty.

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Unilateral fungal keratitis after small-incision lenticule extraction

Cited by 10 publications

References 11 publications

Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

Research progress on animal models of corneal epithelial-stromal injury

Late-Onset Nontuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction

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