Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis

Kasarskis, Edward J.; Hodskins, Jacob; Clair, William H. St.

doi:10.1016/j.jns.2011.06.016

Cited by 27 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anticholinergic drug substances such as Atropine, Benztropine, Glycopyrrolate, and Benzhexol Hydrochloride are some options, which reduce the volume of saliva in the oral cavity by blocking the action of parasympathetic autonomic nervous system on acetylcholine receptors on the salivary glands (Ellies et al, 2006a;Coskun et al, 2007;Bavikatte et al, 2012). Other ways include antihistaminic drugs (Alter, 2010); surgery such as ablation of salivary glands, tympanic neurectomy, transposition or retropositioning of excretory ducts or ligation of excretory ducts (Ellies et al, 2002;Savarese et al, 2004;Manrique et al, 2007); radiotherapy (Bavikatte et al, 2012;Kasarskis et al, 2011;Corso et al, 2011); speech therapy (Crysdale, 1980); techniques of body position, and the "biofeedback" (Tscheng, 2002;Savarese et al, 2004;Bloem et al, 2009;Valencia and Mendoza, 2011).…”

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

View full text Add to dashboard Cite

The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS). Inclusion and exclusion criteria for articles were established, and a total number of 14 articles were selected and used. There are few publications that clarify how the salivary gland acini behave with application of botulinum toxin. Although, the immunohistochemical findings were consistent among authors, showing weak immunoreactivity in glands treated with botulinum toxin. Histometric data are divergent, requiring more detailed studies to answer the questions about the efficacy and safety of botulinum toxin in salivary glands.Keywords: botulinum toxins, salivary glands, sialorrhea, botulinum toxin type A.Achados histológicos e imunohistoquímicos da ação da toxina botulínica em glândula salivar: revisão sistemática ResumoO tratamento da sialorreia se faz necessário pelos constantes riscos trazidos por este estado de hipersalivação. Uma nova opção terapêutica surge com a aplicação da toxina botulínica em glândulas salivares. Entretanto, pouco se sabe sobre o seu mecanismo de ação no tecido glandular. Com base no exposto, este trabalho teve o objetivo de revisar sistematicamente na literatura a ação da toxina botulínica sobre o tecido das glândulas salivares submandibular e parótida. Foi realizada uma busca eletrônica em bases de dados de grande relevância para este estudo (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS e IBECS). Foram estabelecidos critérios de inclusão e exclusão para os artigos, e um "n" de 14 trabalhos foram selecionados e utilizados. São poucas as publicações que esclarecem como os ácinos das glândulas salivares se comportam mediante aplicação da toxina botulínica. Apesar de os achados imunohistoquímicos entre os autores serem concordantes, com imunorreatividade mais fracas nas glândulas tratadas com a toxina botulínica, os dados histométricos são divergentes e há questionamentos metodológicos, necessitando de mais estudos pormenorizados para responder as questões sobre a eficácia e segurança da toxina botulínica nas glândulas salivares.Palavras-chave: toxinas botulínicas, glândulas salivares, sialorreia, toxinas botulínicas tipo A.

show abstract

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

View full text Add to dashboard Cite

show abstract

“…However, this study only represents clinicians managing secretion problems in the UK and therefore neglects treatments such as radiotherapy and tracheostomy which are commonly used outside of the UK [28,29].…”

Section: Discussionmentioning

confidence: 99%

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis

McGeachan

Hobson

Al‐Chalabi

et al. 2016

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

View full text Add to dashboard Cite

Objective: Failure to clear oral secretions can be debilitating for patients with amyotrophic lateral sclerosis, ALS, but the treatment of this symptom is poorly defined and there is no consensus on best practice. The objective of this study was to identify the treatments that are commonly prescribed, and to describe how experienced clinicians manage a patient with treatment resistant symptoms.Methods: Twenty-three clinicians were approached, of which 19 from 16 centres across the UK provided case report forms for a total of 119 ALS patients identified as having problematic oral secretions.Results: The use of five anticholinergics, salivary gland botulinum toxin injections, conservative management approaches and carbocisteine were reported. Of the 72 patients who were evaluated following the initiation of a first anticholinergic, 61% had symptomatic improvement. Only 19% of patients achieved symptomatic improvement with the use of an alternative anticholinergic when an initial anticholinergic achieved no symptomatic improvement. Problems with thick and thin secretions often co-existed with 37% of patients receiving treatment for both types of problem.Conclusion: A variety of treatment options are employed by expert clinicians for problematic oral secretions in ALS patients. The variation in management highlights the need for further prospective research in this area.

show abstract

“…The irradiation treatment was performed with linear accelerator 4-6 MV photons with opposed lateral fields [8][9][10][11][12]. In some studies, 6-15 MeV electrons were utilized [11,12,14]. Whether electron irradiation is associated with less toxicity than photon irradiation, and vice versa, is not possible to conclude from the published data.…”

Section: Discussionmentioning

confidence: 99%

Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

Slade

Stanic

2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis

Cited by 27 publications

References 17 publications

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis

Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

Contact Info

Product

Resources

About