Unique Case Report of Pineal Gland Metastasis From Bladder Carcinoma

Li, Jun; Wang, Ping; Wang, Bin

doi:10.1097/md.0000000000003622

Cited by 11 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pineal metastases are exceedingly rare and considered an incidental finding that occurs late in the course of widely metastatic systemic cancer [ 11 ]. This is the third report of pineal gland metastasis from renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations

Alolyani

Luwimi

Ammar

2021

Cureus

View full text Add to dashboard Cite

Metastases to the pineal gland are rare and reported cases have consisted mainly of lung and gastrointestinal primary malignancies. Here we report the third case in the literature of pineal gland metastasis from renal cell carcinoma.A 69-year-old man, status post excision of right renal cell carcinoma 20 years ago, presented with a onemonth history of urinary incontinence. Images revealed a solitary mass in the pineal region with obstructive hydrocephalus. Endoscopic third ventriculostomy (ETV) and biopsy of pineal mass were performed. The histological diagnosis of the biopsy was inconclusive. The patient was scheduled for a follow-up and readmission for a repeat biopsy, however, was lost to follow-up. No attempts were made by the hospital team or patient relations department to contact him. Eventually, the patient presented after 18 months to the emergency room (ER) with confusion, forgetfulness, gait disturbance, weakness of lower extremities, and vision loss due to enlarged pineal mass. Another ETV and biopsy were performed. The histological findings were compatible with metastasis from renal cell carcinoma. The patient died after three months due to rapid general deterioration in his condition.The lessons that have been learned from this case are: 1) Metastatic tumor should be considered in the differential diagnosis of pineal region tumors, particularly in elderly patients and with a known history of malignancy; 2) If the first biopsy is inconclusive, a rapid plan and a strict follow-up for a repeat biopsy should be made; 3) Elderly patients should have special care; they should be well informed about their condition and should be contacted regularly to ensure that they receive the optimal management plan.

show abstract

Section: Discussionmentioning

confidence: 99%

An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations

Alolyani

Luwimi

Ammar

2021

Cureus

View full text Add to dashboard Cite

show abstract

“…The pineal gland is a rare location for the spread of systemic metastasis. In fact, metastasis to this neuroendocrine secretory circumventricular organ has a reported incidence of 0.4–3.8% of all intracranial metastases ( 1 , 2 ). Although lung cancer is the most common source of disease dissemination to the pineal gland, or epiphysis cerebri, various malignant tumors have been reported to spread to this site including esophageal, stomach, liver, colon, pancreas, kidney, bladder, prostate, thyroid, breast, melanoma, myeloma, and leukemia ( 4 – 6 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…The brain parenchyma is a common site for the dissemination of metastatic disease; however, metastasis to the pineal region is very rare with a reported incidence of 0.4–3.8% of all intracranial metastases ( 1 , 2 ). Since Forster’s original description of the first case in 1858 ( 3 ), various primary malignant tumors have been reported to spread to the pineal region including esophageal, stomach, liver, colon, pancreas, kidney, bladder, prostate, thyroid, breast, melanoma, myeloma, and leukemia ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Metastatic Bronchopulmonary Carcinoid Tumor to the Pineal Region

et al. 2021

View full text Add to dashboard Cite

Intracranial spread of a systemic malignancy is common in advanced staged cancers; however, metastasis specifically to the pineal gland is a relatively rare occurrence. A number of primary lesions have been reported to metastasize to the pineal gland, the most common of which is lung. However, metastasis of a bronchial neuroendocrine tumor to the pineal gland is a seldom-reported entity. Here, we present a 53-year-old female who presented with worsening headaches and drowsiness. MRI brain revealed a heterogeneously enhancing partially cystic mass in the pineal region. The patient had an extensive oncologic history consisting of remote stage IIA invasive breast ductal carcinoma as well as a more recently diagnosed atypical bronchopulmonary neuroendocrine tumor with lymph node metastases. She underwent microsurgical volumetric resection of the large pineal mass and a gross total removal of the tumor was achieved. Histopathology confirmed a metastatic tumor of neuroendocrine origin and the immunohistochemical profile was identical to the primary bronchopulmonary carcinoid tumor. Eight weeks after surgery, she underwent stereotactic radiosurgical treatment to the resection cavity. At 1-year follow-up, the patient remains clinically stable without any new focal neurological deficits and without any evidence of residual or recurrent disease on postoperative MRI. Metastatic neuroendocrine tumors should be considered in the differential diagnosis of pineal region tumors and aggressive surgical resection should be considered in selected patients. Gross total tumor resection may afford excellent local disease control. We discuss the relevant literature on neuroendocrine tumors and current treatment strategies for intracranial metastases of neuroendocrine origin.

show abstract

“…Although the most common metastasis to the pineal region is lung cancer; metastasis from prostate, bladder, breast, esophagus, stomach, colon, melanoma, myeloma have also been reported in the literature. 3,[5][6][7] Metastases are thought to be due to hematogenous spread due to lack of blood-brain barrier in the pineal region. Although pineal metastases are asymptomatic in most cases, headache, Perinaud's syndrome and hydrocephalus may be seen.…”

Section: Discussionmentioning

confidence: 99%

Isolated pineal gland metastasis of acute lymphocytic leukemia: case report

Taydaş

Yesilyurt

Ogul

et al. 2020

Cancer Biology & Therapy

View full text Add to dashboard Cite

Metastasis in the pineal region is a rare condition. To best of our knowledge, there is no case report of isolated pineal metastasis secondary to acute lymphocytic leukemia (ALL). The aim of this study is to show the pineal gland involvement of ALL in a case for the first time in the literature. A 25-year-old male patient diagnosed with ALL 2 years ago presented with headache and visual impairment. Brain magnetic resonance imaging (MRI) revealed a well-defined solid lesion which was revealed intensive enhancement after contrast. On diffusion-weighted images, the lesion showed significant diffusion restriction. Three months after therapy, control MRI demonstrated a completely resorbed pineal lesion. The pineal region may be a possible site of metastasis and involvement due to the absence of a blood-brain barrier, and should not be overlooked in patients with not only solid cancers but also ALL.

show abstract

Unique Case Report of Pineal Gland Metastasis From Bladder Carcinoma

Cited by 11 publications

References 10 publications

An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations

An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations

Case Report: Metastatic Bronchopulmonary Carcinoid Tumor to the Pineal Region

Isolated pineal gland metastasis of acute lymphocytic leukemia: case report

Contact Info

Product

Resources

About