Unique Electrochemiluminescence Behavior of 4-Chromanone and Chromone and their Sensing Application

Abstract

4-Chromanone and chromone, these two structurally similar pharmaceutical intermediates play a vital role in drug synthesis, but their related electrochemical properties have not been reported. In this work, we have found that 4-chromanone and chromone can generate strong electrochemiluminescence (ECL) during their reduction by using K2S2O8 as co-reactant in H3BO3-Na2B4O7 buffer solution. The ECL reaction mechanism has been investigated carefully by studying their fluorescence (FL) spectrum, ECL spectrum, and the important role of co-reactants in the system. Moreover, it has been found that iodide ion (I−) can inhibit the ECL signal of 4-chromanone and the ECL decrease degree is related to the amount of added I−. Therefore, a new ECL method for the detection of iodide ion has been established with high sensitivity, good selectivity and wide linear range, which can be used for detecting I− in real samples.

A Signal Amplification Strategy Using ATP as a Co‐Reaction Accelerator for the Electrochemiluminescence of Ru(bpy)32+/HEPES System and Detection of Iodide Anions**

“…The linear regression equation is I =4034I − +2080 (R 2 =0.9931). The limit of detection (LOD) is calculated by the formula LOD=3Sb/m, where Sb is the standard deviation of the blank measurement, and m is the slope of the calibration curve in the linear area [13b,18] . The limit of detection of I − was calculated to be 3.7×10 −8 m .…”