DeValois and DeValois (1993) showed that to explain hue appearance, S-cone
signals have to be combined with M vs. L opponent signals in two different ways to produce
red-green and yellow-blue axes respectively. Recently, it has been shown that color
appearance is normal for individuals with genetic mutations that block S-cone input to
blue-on ganglion cells. This is inconsistent with the DeValois hypothesis in which
S-opponent konio-geniculate signals are combined with L−M signals at a 3rd
processing stage in cortex. Instead, here we show that color appearance, including
individual differences never explained before, are predicted by a model in which S-cone
signals are combined with L vs. M signals in the outer retina.