Unit activity of the medial wall of the frontal cortex during delayed performance in rats

Батуев, А. С.; Kursina, Natalya P.; Shutov, A. P.

doi:10.1016/0166-4328(90)90145-5

Cited by 65 publications

(34 citation statements)

References 18 publications

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“…These results are consistent with previous reports that showed anticipatory activity from the PFC in delayed working memory tasks. it is well documented that mPFC neurons in rats show sustained activity during the delay period of delay tasks [29,[39][40][41] . in nonhuman primates, the region responsible for working memory is mainly located in the caudal DLPFC [3] .…”

Section: Discussionmentioning

confidence: 99%

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Bai

Liu

et al. 2012

Neurosci. Bull.

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Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role.This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly increased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate (10.86 ± 1.82 spikes/ bin) was higher than the post-event rate (8.17 ± 1.15 spikes/bin) (P <0.05). However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

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Section: Discussionmentioning

confidence: 99%

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Bai

Liu

et al. 2012

Neurosci. Bull.

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“…Much of our understanding of the cellular basis of short-term information storage is based on classic extracellular recording studies that demonstrated persistent spiking of neocortical 3,6,8,27 and hippocampal 4,7 units during the delay period of short-term memory tasks. These studies showed that the particular units recruited during the delay period depended on the stimulus type (e.g., spatial location) and that delay-period activity was typically absent or reduced in trials when the preferred stimulus was presented and the subject made an incorrect behavioral response 3,27 .…”

Section: Relationship To Delay-period Activity Recorded During Workinmentioning

confidence: 99%

“…However, neurons with a diversity of persistent firing durations typically contribute to delay-period activity during working memory tasks and only a fraction are typically active during the entire delay phase. The subset of delay-period neurons with prolonged persistent activity may play a critical role as "summators" that integrate activity from neurons that are active over different time scales 6,8 . While it is difficult to determine the kinetics of the mechanisms underlying persistent activity during working memory tasks since the learned motor output typically extinguishes persistent firing 3 , our experiments demonstrate that the circuitry contained in transverse hippocampal slices, including SGCs with intrinsic persistence, are sufficient to represent information over these long behavioral time scales.…”

Section: Relationship To Delay-period Activity Recorded During Workinmentioning

confidence: 99%

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Mnemonic representations of transient stimuli and temporal sequences in the rodent hippocampus in vitro

Hyde

Strowbridge

2012

Nat Neurosci

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A primary function of the brain is to store and retrieve information. Except for working memory, where extracellular recordings demonstrate persistent discharges during delay-response tasks, it has been difficult to link memories with changes in individual neurons or specific synaptic connections. Here, we demonstrate that transient stimuli are reliably encoded in the ongoing activity of brain tissue in vitro. We found that the patterns of synaptic input onto dentate hilar neurons predict which of four pathways were stimulated with an accuracy of 76% and performed significantly better than chance for >15 s. Dentate gyrus neurons also could accurately encode temporal sequences using population representations that were robust to variation in sequence interval. These results demonstrate direct neural encoding of temporal sequences in the spontaneous activity of brain tissue and suggest a novel local circuit mechanism that may contribute to diverse forms of short-term memory.A fundamental property of the central nervous system is the ability to encode and retrieve information. In mammals, declarative memory function is typically divided into behavioral tasks that promote short-or long-term storage of items such as names, places and specific temporal sequences 1,2 . While the specific cellular origin of individual long-term declarative memories has remained elusive, a large literature highlights the importance of several critical brain regions, including the prefrontal cortex 3 and the hippocampal formation 4 for encoding short-term, or working, memories. Extracellular unit recordings in these brain areas often display periods of persistent spiking activity at elevated frequencies when animals are required to retain transiently presented sensory information. This "delay-period activity" typically lasts for seconds and is extinguished when the animal initiates a behavioral response to indicate whether it correctly remembered the correct transient stimulus 3,5 . The reduction in persistent spiking during error trials-trials in which the animal made an incorrect behavioral response following the delay period-argues that delay-period activity in those specific neurons reflects activity in neural circuits encoding that short-term memory, rather than a response to the cue stimulus or a motor plan Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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“…Many more studies show that rats with mPFC lesions are impaired on tasks requiring a delay between stimulus and response (for review, see Kesner, 2000;Uylings et al, 2003). As in the primate dorsolateral PFC, cells in rat mPFC exhibit extended firing during delay periods on working memory tasks (Sakurai and Sugimoto, 1986;Batuev et al, 1990;Mulder et al, 2000;Chang et al, 2002;Baeg et al, 2003). The electrophysiological evidence for delay-related activity, however, is equivocal.…”

Section: Introductionmentioning

confidence: 99%

Apparent Encoding of Sequential Context in Rat Medial Prefrontal Cortex Is Accounted for by Behavioral Variability

Euston¹,

McNaughton²

2006

J. Neurosci.

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Simple sequences can be represented via asymmetrically linked neural assemblies, provided that the elements of the sequence are unique. When elements repeat, however (e.g., A-B-C-B-A), the same element belongs to two separate "sequential contexts," and a more complex encoding mechanism is required. To enable correct sequence performance, some neural structure must provide a disambiguating signal that differentiates the two sequential contexts (i.e., B as an element of "A-B" as opposed to "C-B"). The disambiguating signal may derive from a form of working memory, or, in some cases, a simple timing mechanism may suffice. To investigate the possible role of medial prefrontal cortex in complex sequence encoding, rats were trained on a spatial sequence containing two adjacent repeated segments (e.g., A-B-C-D-B-C-E). The double-repeat procedure minimized behavioral differences in the second leg (C) of the repeat subsequence that arise in the first leg (B) because of differences in the entry point (e.g., A-B vs D-B). Far more cells were context sensitive along the first leg than along the second (36 vs 9%), and most of the differences were accounted for by systematic variations in the rat's trajectory, which were much larger along the first leg. There is thus little evidence for sequential context-discriminative activity in the medial prefrontal cortex that cannot plausibly be accounted for by context-dependent behavior. The finding that the rodent medial prefrontal cortex is highly sensitive to sensory-behavioral variables raises doubts about previous experiments that purport to show working memoryrelated activity in this region.

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Unit activity of the medial wall of the frontal cortex during delayed performance in rats

Cited by 65 publications

References 18 publications

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Mnemonic representations of transient stimuli and temporal sequences in the rodent hippocampus in vitro

Apparent Encoding of Sequential Context in Rat Medial Prefrontal Cortex Is Accounted for by Behavioral Variability

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