2019
DOI: 10.1002/smll.201905421
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Universal Nanocarrier Ink Platform for Biomaterials Additive Manufacturing

Abstract: Ink engineering is a fundamental area of research within additive manufacturing (AM) that designs next‐generation biomaterials tailored for additive processes. During the design of new inks, specific requirements must be considered, such as flowability, postfabrication stability, biointegration, and controlled release of therapeutic molecules. To date, many (bio)inks have been developed; however, few are sufficiently versatile to address a broad range of applications. In this work, a universal nanocarrier ink … Show more

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Cited by 41 publications
(34 citation statements)
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“…PNP hydrogels rely on multivalent, noncovalent interactions between polymers and the surfaces of adjacent nanoparticles to create dynamic crosslinks. [ 8,18,19,45–48 ] Alginate hydrogels form dynamic crosslinks through ionic interactions between divalent cations and carboxylate groups on alginate's guluronate residues and are the most commonly used biomaterial. [ 25,49–52 ] Additionally, most rheological data for PHs, regardless of their crosslinking mechanism, have demonstrated power‐law shear‐thinning behavior in shear flow.…”
Section: Resultsmentioning
confidence: 99%
“…PNP hydrogels rely on multivalent, noncovalent interactions between polymers and the surfaces of adjacent nanoparticles to create dynamic crosslinks. [ 8,18,19,45–48 ] Alginate hydrogels form dynamic crosslinks through ionic interactions between divalent cations and carboxylate groups on alginate's guluronate residues and are the most commonly used biomaterial. [ 25,49–52 ] Additionally, most rheological data for PHs, regardless of their crosslinking mechanism, have demonstrated power‐law shear‐thinning behavior in shear flow.…”
Section: Resultsmentioning
confidence: 99%
“…This is an asset that has been difficult to achieve with previously reported 3D printed hydrogels. [59][60][61] To exploit this new feature, we 3D print our jammed microgels into high aspect ratio hollow cylinders, as shown in Figure 7a. Indeed, the additive manufactured DNGH structure can be repetitively compressed up to 80%, where it buckles, and retains its initial shape when the stress is released, as shown in Movie S3, Supporting Information.…”
Section: Potential Applications Of Dnghsmentioning
confidence: 99%
“…An emerging application of polymeric NPs is as building blocks for the assembly of PNP hydrogels (Appel et al, 2015a,b;Guzzi et al, 2019;Lopez Hernandez et al, 2019;Stapleton et al, 2019;Steele et al, 2019). PNP hydrogels form spontaneously upon simple mixing of an appropriately paired polymer, e.g., hydroxypropylmethylcellulose (HPMC) or C12-functionalized hyaluonic acid, and a concentrated solution of core-shell NPs under aqueous conditions.…”
Section: Fabrication Of Polymer-nanoparticle (Pnp) Hydrogelsmentioning
confidence: 99%
“…Beyond the use of core-shell NPs as a stand alone delivery vector, they have recently been exploited as building blocks in the assembly of shear-thinning and selfhealing, polymer-nanoparticle (PNP) hydrogels for site specific delivery following local injection (Appel et al, 2015b). PNP hydrogels have also been used as nanocarrier bioinks for additive manufacturing, as a sprayable barrier to prevent tissue adhesion following cardiothoracic surgery, and as a depot for the local release of cytokines and recruitment of immune cells (Fenton et al, 2019;Guzzi et al, 2019;Lopez Hernandez et al, 2019;Stapleton et al, 2019).…”
Section: Introductionmentioning
confidence: 99%