“…The questionnaire was based on the II Second National Survey on Drugs and Alcohol 25 , whose questions evaluated both lifetime and 30 days prior consumption categorized into the following rates: 0 = no use, 1 = used one drug, 2+ = used two or more drugs. Independent variables were: sex (female, male); age (18)(19)(20)(21)(22), and ≥ 23 years), used to avoid categories with very few individuals; skin color (white, black/brown/other); marital status (married or single/separated/widowed); religious practice (yes, no); living situation (with family/partner, alone, with friends); socioeconomic level (based on Brazilian Association of Research Companies [Abep] criteria: classes A, B, C, D and E) 26 ; major depression (based on the Patient Health Questionnaire-9, with a cutoff point of ≥ 9); 27 stressful events (including giving up or postponing important moments of leisure, having financial problems or feeling worried, anxious, discouraged, or tense because of the academic activities; feeling alone or lacking support; suffering discrimination from peers or professors; being pressured to perform well; being verbally or physically assaulted by peers; experiencing conflict with professor(s); undergoing changes in living habits; being disappointed with teaching quality), scored on the following scale: happened, but did not affect me; happened, but I was little affected; happened, and I was partially affected; happened and deeply affected me; did not happen to me. The last variable was dichotomized later, with stressor events coded as "yes" only in cases in which participants reported having been deeply affected by at least one event; area of major (exact sciences and soil sciences/agronomy, health and biological sciences, applied social sciences and humanities, linguistics, arts and languages), morning or evening classes, and age of first experience with alcohol, tobacco or drugs (< 18 or ≥ 18 years).…”