In Ghana, the education sector has been one of the most affected sectors since the emergence of COVID-19. The plights of low-fee private schools (LFPSs) in the country could be exacerbated by the closure of schools due to COVID-19. This study investigated the online learning resources, challenges, and coping strategies of LFPSs during the closure of schools in Ghana due to COVID-19 pandemic. Google Form was used to gather data from 67 heads of LFPSs in Ghana between April and June 2020. We found that about one-fifth of LFPSs used online learning before the emergence of the COVID-19 pandemic. Most LFPSs acquired an online learning resource due to COVID-19. However, heads of LFPSs had mixed perceptions of online learning. Also, the closure of schools affected school finances; teaching, learning and assessment of students; and the ability to pay teachers’ salaries. To cope with their challenges, heads of LFPSs used strategies such as staff lay off; online learning and giving assignments; and the distribution of food items and personal protective equipment. The study recommends the following: there is a need for in-service training for teachers on online learning, improvement in the information and communication technology (ICT) infrastructure across the country, and subsidization of ICT resources. Also, the Government of Ghana should provide tax relief to telecommunication companies that improve their infrastructure and expand their coverage across the country to enhance internet accessibility and connectivity.