Unknown face of known drugs – what else can we expect from angiotensin converting enzyme inhibitors?

Wzgarda, Anna; Kleszcz, Robert; Prokop, Monika; Regulska, Katarzyna; Regulski, Miłosz; Paluszczak, Jarosław; Stanisz, Beata

doi:10.1016/j.ejphar.2016.12.031

Cited by 14 publications

(15 citation statements)

References 132 publications

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“…In more detail, RAS activation results in enhanced VEGF, which in turn increases angiogenesis and pro-tumorigenic transcription factors. The local RAS system also engages in invasion, migration and metastasis as well as pro-inflammatory process [19]. Recently, tumor-inhibitory ability of telmisartan, an ARB, has been demonstrated by in vivo and in vitro Min Ae Cho, Impact of Antihypertensive Drugs on EOC Survival experiments on esophageal squamous cell carcinoma [20].…”

Section: Discussionmentioning

confidence: 99%

Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients

et al. 2020

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PurposeWe investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes in epithelial ovarian cancer (EOC).Materials and MethodsA single-institutional retrospective chart review of 878 patients with EOC was performed. Survival was compared according to use of the four antihypertensive medications during primary treatment. Propensity score matching (ratio 1:3) was performed to control possible associated covariates, such as age, International Federation of Gynecology and Obstetrics stage, residual status after primary debulking surgery, and co-morbidity.ResultsAmong 878 patients, 56 patients (6.4%) were ARB users, 62 (7.1%) were BB users, 107 (12.2%) were CCBs users and 32 (3.6%) used TDs. Median progression-free survival (PFS) for ARB, BB, and CCB users was 37.8, 27.2, and 23.6 months compared with 33.6 months for non-users. ARB was associated with 35% decreased risk of disease progression (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.42 to 0.99; p=0.046) in multivariate analysis. After propensity score matching, median PFS for ARB users was 37.8 months and ARB use remained to be associated with lower recurrence rate in univariate (p=0.035) and multivariate analysis (HR, 0.60; 95% CI, 0.39 to 0.93; p=0.022).ConclusionIn this study, ARBs use during primary treatment is associated with lower recurrence in EOC patients. However, CCBs, BBs, and TDs did not show beneficial impact.

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Section: Discussionmentioning

confidence: 99%

Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients

et al. 2020

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“…Current findings have indicated that ACE inhibitors may increase NO bioavailability and reduce oxidative and nitrosative stress parameters during hypertension. These effects provide an additional cardioprotective response to the sustained antihypertensive effect [ 19 ]. Therefore, considering our findings, ENAL was presented as a standard drug for comparison with the cardioprotective potential of ESAH.…”

Section: Discussionmentioning

confidence: 99%

Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension

Palozi

Schaedler

Tirloni

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery. Enalapril (15 mg/kg) and hydrochlorothiazide (25 mg/kg) were used as standard drugs. Diuretic activity was evaluated on days 1, 7, 14, 21, and 28. Systolic, diastolic, and mean blood pressure and heart rate were recorded. Serum creatinine, urea, thiobarbituric acid reactive substances, nitrosamine, nitrite, aldosterone, vasopressin levels, and ACE activity were measured. The vascular reactivity and the role of nitric oxide (NO) and prostaglandins (PG) in the vasodilator response of ESAH on the mesenteric vascular bed (MVB) were also investigated. ESAH treatment induced an important saluretic and antihypertensive response, therefore recovering vascular reactivity in 2K1C plus OVT-rats. This effect was associated with a reduction of oxidative and nitrosative stress with a possible increase in the NO bioavailability. Additionally, a NO and PG-dependent vasodilator effect was observed on the MEV.

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“…Calibration was Table 1. Physical and pharmacokinetic properties of selected ACE-I: t max -time to reach peak serum concentration, c max -maximum serum concentration, f b -protein binding, F-bioavailability, BBB -penetrating the blood-brain (1,4,21…”

Section: Chemicalsmentioning

confidence: 99%

“…What is more, in the clinical trials ACE-I are also reported as very beneficial for patients with comorbidities, and the positive effects can be found beyond the circulatory system. (3)(4)(5). A feature connecting pleiotropic activity of this group of drugs is the fact that the positive influence can be associated with inhibition of reactive oxygen species (ROS) and inflammation processes.…”

mentioning

confidence: 99%

Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method

Ramos¹,

Juszczak²,

Szczołko³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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A negative impact of radicals on humanís health is responsible for growing research interest in antioxidant properties of substances, which protect organisms from the damaging influence of these reactive species. Angiotensin-converting enzyme inhibitors (ACE-I) are the most popular drugs used in cardiovascular diseases. There are a lot of clinical reports that ACE-I have antioxidant properties, due to the fact, that prolonged use improves conditions of patients with neurodegenerative disorders and slow inflammatory processes. The paper shows the antioxidant properties of a selected ACE-I: cilazapril, ramipril, imidapril, lisinopril, perindopril, and quinapril. Among numerous methods for antioxidant activity estimation, DPPH reduction is the most popular and commonly used one due to its ease, speed, sensitivity and the usage of stable radicals. UV-Vis spectrophotometry was used to examine interactions of chosen ACE-I with model-free radicals. Absorption of UV-Vis spectra of DPPH (reference), and DPPH interacting with the tested ACE-I were compared. For all tested ACE-I kinetics of their interaction with DPPH, up to 30 min, were obtained. The strongest interaction with DPPH was observed for imidapril and cilazapril and the lowest interaction for lisinopril. Studies have shown usefulness UV-Vis spectrophotometry for obtaining information on interactions of ACE-I with modelfree radicals.

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Unknown face of known drugs – what else can we expect from angiotensin converting enzyme inhibitors?

Cited by 14 publications

References 132 publications

Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients

Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients

Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension

Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method

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