Unlimited Survival of Homologous Kidney Grafts in Dogs

Induced Tolerance of a Kidney Allograft in a Pig

“…Such induced immunological tolerance of allogeneic tissue has not been easily achieved in large domestic animals, but P uza and G ombos. in a series of paper [5][6][7] described induction of tolerance in dogs, of skin and kidney allografts by neonatal exchange transfusion. Recently others have induced tolerance in dogs, of kidney and lung allografts by repeat ed neonatal injection of donor marrow [8] and of allogeneic tumours by injection of tumour cells in the foetus [9], The immune responses of pigs are in most respects typical of mam mals.…”