Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer

Liu, Shao-Hsiang; Chen, Po-Sheng; Huang, Chun‐Chieh; Hung, Y. Elizabeth; Lee, Mei-Ying; Lin, Wei-Chiang; Lin, Yuan–Ching; Lee, Alan Yueh‐Luen

doi:10.3389/fphar.2020.601785

Cited by 28 publications

(20 citation statements)

References 104 publications

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“…Traditional Chinese medicine (TCM) has been widely used as an adjuvant therapeutic option for cancer treatment ( Xiang et al, 2019 ; Liu S.-H. et al, 2021 ). High-level clinical studies of TCM injection in cancer care has gradually increased ( Yang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Kanglaite Combined With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy for Stage III/IV Non-Small Cell Lung Cancer: A PRISMA-Compliant Meta-Analysis

Kong

Wang

et al. 2021

Front. Pharmacol.

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Objective: Kanglaite(KLT), a type of Chinese medicine preparation, is considered as an adjuvant therapeutic option for malignant cancer treatment. This study aimed to systematically investigate the efficacy and safety of the combination of KLT and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for the treatment of stage III/IV non-small cell lung cancer.Methods: Randomized controlled trials (RCTs) that compared KLT plus EGFR-TKI with EGFR-TKI alone for the treatment of stage III/IV non-small cell lung cancer were reviewed. Literature searches (up to July 10, 2021) were performed on PubMed, Web of Science, Cochrane Library, Embase, ClinicalTrials.gov, China National Knowledge Infrastructure (CNKI), Wanfang Database, and the Chinese Scientific Journal Database. Two researchers independently assessed the risk of bias with the tool of Cochrane Collaboration. RevMan 5.3.0 was used in the analysis of the included trial data.Results: 12 RCTs recruiting 1,046 patients with stage III/IV NSCLC were included. Results showed that compared with EGFR-TKI alone, KLT plus EGFR-TKI significantly increased the disease control rate (DCR) (odds ratio [OR]=3.26; 95% confidence interval [CI]:2.22–4.77; p < 0.00001), the objective response rate (ORR) (OR=2.59; 95% CI:1.87–3.58; p < 0.00001) and Karnofsky performance status (KPS) (OR = 2.76; 95% CI:1.73–4.39; p < 0.00001). Furthermore, patient immunity was enhanced with KLT plus EGFR-TKI. The combined treatment increased the percentage of CD4 + T cells (weighted mean difference [WMD]=5.36; 95% CI:3.60–7.13; p < 0.00001),the CD4+/CD8 + ratio (WMD = 0.18; 95% CI: 0.08–0.27; p = 0.004), and percentage of NK cells (WMD=4.84; 95% CI: 3.66–6.02; p < 0.00001).With regard to drug toxicity, the occurrence rate of nausea and vomiting was significantly reduced by KLT plus EGFR-TKI (OR=0.37; 95% CI: 0.16–0.86; p = 0.02).Conclusion: KLT plus EGFR-TKI was effective in treating stage III/IV non-small cell lung cancer. Thus, its application in these patients is worth promoting. Additional double-blind, well-designed and multicenter RCTs are required to confirm the efficacy and safety of this treatment.

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Section: Introductionmentioning

confidence: 99%

Kanglaite Combined With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy for Stage III/IV Non-Small Cell Lung Cancer: A PRISMA-Compliant Meta-Analysis

Kong

Wang

et al. 2021

Front. Pharmacol.

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“…Traditional Chinese medicine is characterized by multiple targets and remarkable curative effect, and has been applied to cure various diseases, especially cancers (Fan et al, 2020; Liu et al, 2021; Wang et al, 2021). For example, SA, which is a natural active substance, that could be extracted from fruits, vegetables, cereals, and oil crops, has been reported to have certain biological properties.…”

Section: Discussionmentioning

confidence: 99%

Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of theAKT/Gsk‐3β signal pathway

et al. 2021

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Among digestive system cancers, the extremely poor prognosis of pancreatic cancer (PC) is a pressing concern. Nonoperative treatments such as targeted and immunotherapy, have improved the current situation, however, the accompanying side effects of these chemicals should not be ignored. Here, we discovered a novel hydroxycinnamic acid named sinapic acid (SA) derived from fruits, vegetables, cereals, and oil crops as an effective anti‐PC molecule. Both the in vitro and in vivo models we designed showed that SA exhibited anticancer activities but not apoptosis induction. Research on the underlying mechanisms illustrated that AKT phosphorylation was blocked by SA, and the downstream Gsk‐3β was downregulated subsequently. Our study revealed the inhibitory activity and underlying mechanisms of SA, providing evidence that SA is a potential strategy for cancer research and can be a promising option of PC chemotherapy.

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“…Traditional Chinese medicine (TCM) is a conjugative discipline, combining personalized medicine with therapeutics and cancer therapy. However, a greater part of the patients presently uses TCM as an alternate method of pain alleviation rather than the main method of treatment, despite the fact that it has been directly associated with treating major diseases such as cancer in recorded medical history [ 48 ].…”

Section: Treatment Of Gc: Conventional and Modern Methodsmentioning

confidence: 99%

“…The fruit of I. verum is reported to contain various alkaloids, essential oils, and tannins, with significant amounts of cis- and trans-anethole, limonene, safrole, α - and β -pinene, β -phellandrene, α -terpineol, and farnesol [ 70 ]. Flavonoids like quercetin and kaempferol and their glucosides, phenolic compounds like shikimic acid, and fatty acids such as linoleic, myristic, stearic, betunolic, and phenyl propionic acid are also reported to be active constituents of ASF [ 48 , 71 ]. Furthermore, the essential oils of ASF are comprised of flavonoids, terpenes, sesquiterpenes, and lignans which are equally significant respective to their medicinal and therapeutic properties.…”

Section: An Example Of Tcm: Asf and Its Activity Against Gcmentioning

confidence: 99%

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

Khan

Shamim

2022

Evidence-Based Complementary and Alternative Medicine

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Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F. (Chinese star anise), which is native to many countries, and is a significant Chinese medicinal herb. Gastric cancer (GC) is one of the major fatal types of cancers with multiple stages and a poor prognosis. The present review aims to discuss the bioactive properties of ASF and its phytocompounds against GC, with a particular insight into the molecular mechanisms and signaling pathways involved in its anti-GC mechanism. Furthermore, it highlights the potential mechanism of action of major phytocompounds of ASF against GC. Clinical studies (in vitro and in vivo) regarding the action of ASF and its major bioactive compounds such as quercetin, luteolin, kaempferol, d-limonene, and honokiol against GC were reviewed. For this review, search of literature was performed in Science, PubMed, Google Scholar, Web of Science, and Scopus related to ASF and its phytocompounds, from which only relevant studies were chosen. Major bioactive compounds of ASF and their extracts have proven to be effective against GC due to the mechanistic action of these compounds involving signaling pathways that target cancer cell apoptosis, proliferation, and tumor metastasis in GC cells. Existing reports of these compounds and their combinatory effects with other modern anticancer agents have also been reviewed. From its traditional use to its role as an anticancer agent, ASF and its bioactive phytocompounds have been observed to be effective in modern research, specifically against GC. However, further studies are required for the identification of molecular targets and pharmacokinetic potential and for the formulation of anti-GC drugs.

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Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer

Cited by 28 publications

References 104 publications

Kanglaite Combined With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy for Stage III/IV Non-Small Cell Lung Cancer: A PRISMA-Compliant Meta-Analysis

Kanglaite Combined With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy for Stage III/IV Non-Small Cell Lung Cancer: A PRISMA-Compliant Meta-Analysis

Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of theAKT/Gsk‐3β signal pathway

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

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