Unmet Medical Needs in High-Risk Cardiovascular Patients With Familial Hypercholesterolemia

Abstract

Cardiovascular (CV) diseases are a major burden for all the healthcare systems around the world. Public health and medical advances continue to beneficially affect CV patients health. In the last decades, many new medicinal products for hearth problems were discovered and received a marketing authorization. Elevated low-density lipoprotein cholesterol (LDL-C) levels have been linked to major CV risk. The objective of this study was to review the medical needs in high-risk cardiovascular patients with familial hypercholesterolemia undergoing pharmacological treatment with statins and the degree of attained lipid control. A conclusion it can be stated, that there is a significant unmet medical need for a potentially effective treatment, which can supplement the statin therapy, enabling vulnerable populations to achieve sufficient control of LDL-C, and thus provide an alternative for patients with statin intolerance or where this group of medicinal products are not clinically appropriate.

Genetic polymorphisms predisposing to common cardiovascular diseases

“…Мета-анализ, включващ 23846 тест-субекта, изследващ асоциацията на АРОС3 полиморфизма и нивата на АРОС3, триглицериди, общ холестерол, LDL-холестерол и HDL-холестерол, също доказва асоциацията на GG генотипа с повишен риск от дислипидемия (25). Съществуват и незадоволени медицински нужди при високорисковите сърдечносъдови пациенти с фамилна хиперхолестеролемия (26).…”