Unmonitored use of herbal medicine by patients with breast cancer: reframing expectations

Samuels, Noah; Ben‐Arye, Eran; Maimon, Yair; Berger, Raanan

doi:10.1007/s00432-017-2471-x

Cited by 24 publications

(21 citation statements)

References 22 publications

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“…It is pivotal that the providers' approach acknowledges the value of CAM products if used properly rather than dismissing them in favor of conventional treatments [ 6 ]. This will minimize patients' resistance to disclosing CAM use and will help integrate CAM products and services into conventional treatment [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Understanding CAM Use in Lebanon: Findings from a National Survey

Kharroubi

Chehab

El-Baba

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The main objective of this study was to identify predictors of Complementary and Alternative Medicine (CAM) use in Lebanon. Data for this study were drawn from a national survey conducted among Lebanese adults (n=1500). A modified version of the Social Behavioral Model (SBM) was used to understand CAM use in the study population. In this version, predisposing factors included sociodemographic characteristics (age, gender, education, and employment) and Push and Pull factors. Additionally, enabling resources included income, and medical need encompassed presence of chronic disease and perceived health status. Simple and multiple logistic regressions were used to examine the predictors of CAM use in the study population. Results of the multiple logistic regression showed that younger and older adults were less likely to use CAM as compared to middle-aged respondents. The Push factor “dissatisfaction with conventional medicine” was associated with higher odds of CAM use. For three of the six Pull factors, compared to participants who strongly disagreed, those who had a tendency of taking care of one's health were more likely to use CAM. Income and presence of chronic disease were also associated with higher odds of CAM use. The findings of this study affirmed the utility of the SBM in explaining the use of CAM and proposed a new version of this model, whereby the Push and Pull factors are integrated within the predisposing factors of this model.

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Section: Discussionmentioning

confidence: 99%

Understanding CAM Use in Lebanon: Findings from a National Survey

Kharroubi

Chehab

El-Baba

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Investigations revealed that the use of herbal medicines, usually as the complementary and alternative treatment, increased dramatically and became popular around the world (Ramos-Remus and Raut, 2008 ; Harris et al, 2012 ; Putthapiban et al, 2017 ). Meanwhile, the safety of herbal medicine and herbal-drug interactions have been highlighted and drawn extensive attention from the medical community (Brazier and Levine, 2003 ; Samuels et al, 2017 ; Singh and Zhao, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Cytochrome P450-Mediated Metabolism Alternation of Four Effective Lignans From Schisandra chinensis in Carbon Tetrachloride-Intoxicated Rats and Patients With Advanced Hepatocellular Carcinoma

Xiao²,

Zhang³

et al. 2018

Front. Pharmacol.

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It is highly valuable to study the pharmacokinetics of herbal components under the pathological condition of liver dysfunction for safe and rational use of herbal medicines. In this study, the pharmacokinetic profiles of four effective lignans from Schisandra chinensis (SC), schisandrin, schisantherin A, deoxyshisandrin and γ-schisandrin, were investigated in carbon tetrachloride (CCl4)-intoxicated rats. The metabolism of the four lignans was also studied using microsomes from patients with advanced hepatocellular carcinoma. In situ intestinal and hepatic perfusions were conducted to clarify the contributions from impairments of gut and liver on the pharmacokinetics of the four schisandra lignans in CCl4-intoxicated rats. The metabolism in rat and human liver microsomes and transport in Caco-2 monolayer cell model were studied to reveal the key factors for the in vivo disposition of the four lignans. When SC alcoholic extract was orally administrated to CCl4-intoxicated rat for a short term (4 days), the pharmacokinetics of four active SC lignans was significantly changed while its hepatotherapeutic effect was not obviously observed. The plasma concentrations of the four schisandra lignans were dramatically elevated compared with the control. The Cmax, AUC and MRT were all increased or prolonged significantly while parameter CLz/F was obviously reduced in rat pretreated with CCl4. In hepatic perfusion study and liver microsomes incubation, it was found that the hepatic metabolism of the four lignans was markedly decreased mainly due to the activity reduction of multiple CYP450 isoenzymes involved the metabolism, which, eventually, might lead to the alternation of their pharmacokinetic profiles in CCl4-intoxicated rats or patients with advanced hepatocellular carcinoma. The pharmacokinetic studies of SC components in pathological situation of liver dysfunction are expected to provide useful data for rational and safe application of SC preparations in clinic or further pharmacological and toxicological research.

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“…The benefits of complementary medicines in helping patients endure traditional treatments have already been described (Ludwick et al., 2020; Shalom‐Sharabi et al., 2017), though the methodology of studies on complementary medicines is often weak (Lee, Choi, & Hyun, 2019). Moreover, adverse interactions between complementary medicines and conventional treatment (Velicer & Ulrich, 2008) and the risk of patients delaying or discontinuing conventional treatment have both been seen to be associated with reductions in survival in complementary medicine users (Greenlee et al., 2016; Johnson et al., 2018a; Johnson, Park, Gross, & Yu, 2018b; Samuels, Ben‐Arye, Maimon, & Berger, 2017).…”

Section: Discussionmentioning

confidence: 99%

Patient perspectives on supportive care in cancer: Results of the Calista 2 study

Simon¹,

Ganem

Touboul³

et al. 2020

Eur J Cancer Care

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Over recent decades, the management of cancer patients has improved as a result of earlier diagnosis, better management of side effects, and more effective therapies. The question of patient quality of life-both during and following cancer treatment-consequently requires greater attention than has previously been the case, with supportive and palliative care playing a particularly important role. Dedicated clinical practice guidelines are regularly updated to improve of the management of a variety of issues, both during and after the active disease stage. Patient-reported outcome measures have emerged as an important aspect of improving quality of life in a period of patient-centred

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Unmonitored use of herbal medicine by patients with breast cancer: reframing expectations

Cited by 24 publications

References 22 publications

Understanding CAM Use in Lebanon: Findings from a National Survey

Understanding CAM Use in Lebanon: Findings from a National Survey

The Cytochrome P450-Mediated Metabolism Alternation of Four Effective Lignans From Schisandra chinensis in Carbon Tetrachloride-Intoxicated Rats and Patients With Advanced Hepatocellular Carcinoma

Patient perspectives on supportive care in cancer: Results of the Calista 2 study

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