Unnatural Base Pairs for Synthetic Biology

N-Methoxy-1,3-oxazinane nucleic acids (MOANAs) – a configurationally flexible backbone modification allows post-synthetic incorporation of base moieties

“…Modified or completely artificial base moieties can imbue oligonucleotides with new properties, such as alternative base pairing patterns, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] catalytic activity 17,18 or the ability to bind metal ions, either coordinatively [19][20][21][22][23][24] or through formation of a carbon-metal bond. 25,26 Unnatural base moieties are most commonly introduced into oligonucleotides as phosphoramidite building blocks of the corresponding nucleoside analogues by automated solid-phase synthesis.…”

Chlorosulfonic acid coated on porous organic polymer as a bifunctional catalyst for the one-pot three-component synthesis of 1,8-naphthyridines

“…[36][37][38] A variety of 1,8-naphthyridines derivatives, namely jasmine, perolidine, and sublin, are used directly as antibacterial, antiviral, anti-inammatory, antitumor, and antioxidant (Scheme 1). [39][40][41][42] Despite the synthetic methods described for syntheses of these materials, [43][44][45] we believe there is still work to do in this eld. Hence, it is necessary to develop additional green, atom-efficient, sustainable, and high-yielding methods for synthesizing these compounds.…”

Extended nucleic acid memory as the future of data storage technology

“…The concept of non-standard nucleotide gained its popularity over the last few years. The non-standard nucleotides were chemically designed in such a manner that the complementary base pairs are highly specific and selective in nature (Malyshev et al, 2014;Saito-Tarashima et al, 2018).…”