Global warming and rapid socioeconomic development increased the risk of regional and global disasters. Particularly in China, annual heatwaves (HWs) caused many fatalities and substantial property damage, with an increasing trend. Therefore, it is of great scientific value and practical importance to analyze the spatiotemporal changes of HW in China for the sustainable development of regional socioeconomic and disaster risk management. In this study, based on gridded maximum temperature product and specific humidity dataset, an HW evaluation algorithm, considering the impact of humidity on the human body and the characteristics of HW in China, was employed to generate daily HW state at light, moderate, and severe levels for the period 1979–2018. Consequently, the regional differences at three HW levels were revealed, and the changing trend of HW onset, termination, and duration in each subregion was analyzed. The results show that in the three levels, the frequency and duration of HW in China had a significant increasing trend, generally characterized by the advancement of HW onset and the postponement of HW termination. The HW influence at light, moderate and severe levels decreased gradually, with the light level occurring the earliest and terminating the latest. Among the seven subregions, the largest HW frequency happened to be mainly in XJ (Xinjiang), SC (Southern China), and NC (Northern China), while the variations of HW onset and termination had noticeable regional differences at the three levels. The findings presented in this study can provide the essential scientific and technological support for national and regional disaster prevention mitigation and adaptation to extreme climate events.