Unraveling cancer lineage drivers in squamous cell carcinomas

Guan, Yinglu; Wang, Guan; Fails, Danielle; Nagarajan, Priyadharsini; Ge, Yejing

doi:10.1016/j.pharmthera.2019.107448

Cited by 24 publications

(24 citation statements)

References 419 publications

(353 reference statements)

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“…with cSCC, 101 further strengthening the notion that deregulation of squamous lineage TFs constitutes a signature for this type of skin malignancy.…”

Section: Squamous Tf Deregulation In Csccsupporting

confidence: 57%

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Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Guan

Yang

Nagarajan

et al. 2020

Experimental Dermatology

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As the largest organ of the human body, our skin serves as a physical barrier between the individual and the environment. The skin preserves body fluid, guards against irradiation and pathogens and conducts sensations. The epidermis is composed of several epithelial layers. The basal cells attach to the basement membrane above the dermis, joined by hemidesmosomes and adherens junctions, and are home to the epidermal stem cells (EpdSCs), which undergo long-term self-renewal and continuously fuel the upward flux of differentiating cells, forming the skin barrier. 1 EpdSC progenies transition through the multiple differentiated layers, starting with the suprabasal spinous layer, rich in desmosomes 2 ; then the granular layer, containing keratohyalin and lamellar granules; and finally the stratum corneum, composed of flattened denucleated corneocytes with heavily crosslinked keratin cables and a cornified envelope, eventually sloughed off the skin surface. 3 Connecting to the epidermis are many epidermal appendages, among which the most abundant are the sweat glands and the pilosebaceous units. Sweat glands are responsible for thermoregulation, 4,5 while the pilosebaceous unit is composed of

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“…with cSCC, 101 further strengthening the notion that deregulation of squamous lineage TFs constitutes a signature for this type of skin malignancy.…”

Section: Squamous Tf Deregulation In Csccsupporting

confidence: 57%

“…Like EGF signalling, 193,194 FGF signalling is heavily involved in epithelial growth, wound repair, inflammation and tumorigenesis, 195,196 and both pathways are frequently altered in human SCCs. 101…”

Section: (A) (B) (C) ( D)mentioning

confidence: 99%

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Guan

Yang

Nagarajan

et al. 2020

Experimental Dermatology

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“…SCC is a tumor of the epithelial tissue that typically originates from the epithelial linings of the skin, respiratory tract, digestive tract, and reproductive tract; thus, SCC can involve the head and neck, esophagus, lungs, cervix, and genital area[ 8 ]. Epithelial linings can be divided into layered squamous epithelium and non-squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…SCC-derived cells share a common feature, in that they originate due to the mutation of proliferative basal cells, which are characterized by their ability to self-renew and produce terminally differentiated cells. Under the influence of oncogenic genes, both stem and progenitor cells can act as the origin cells of cancer[ 8 ]. A comparison of different SCCs shows that they are characterized by very similar mutant genes, including TP53 , SOX2 , TP63 , CDNK2A ( P16-INK4A ), NOTCH1 , KMT2D , PIK3CA , and PTEN [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Primary nonkeratinizing squamous cell carcinoma of the scapular bone: A case report

Zuo

Tang

et al. 2021

WJCC

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BACKGROUND Squamous cell carcinoma (SCC) of bone is usually caused by metastasis from the lungs, bladder, or other sites. Primary SCC of bone most frequently involves the skull bones, and primary involvement of other sites in the skeletal system is extremely rare. To date, only three such cases have been reported, which makes the diagnosis, treatment, and prognosis of this disease a challenge. CASE SUMMARY A 76-year-old Chinese man presented to our hospital with nonspecific pain and limited mobility in the right shoulder for 4 mo. He underwent three-dimensional computed tomography reconstruction and magnetic resonance imaging of the right shoulder, which revealed an osteolytic destructive lesion in the right scapula with invasion into the surrounding muscles and soft tissues. Ultrasound-guided core needle biopsy detected a malignant tumor, and immunohistochemical analysis revealed a poorly differentiated SCC. Wide excision of the right scapular bone was performed, and pathological examination of the surgical specimen confirmed the diagnosis. At the last follow-up examination within 2 years, the patient was doing well with the pain significantly relieved in the right shoulder. CONCLUSION Primary SCC of bone is extremely rare at sites other than the skull. Clinicians must exhaust all available means for the diagnosis of primary SCC of the bone, so greater attention can be paid to its timely and effective management. Regular and adequate follow-up is essential to help rule out metastasis and judge the prognosis.

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“…One explanation of the concordant histology between EC and subsequent LC might be exposure of the epithelium of lung and upper aerodigestive tract to some of the same carcinogens. Besides, Several master development regulators were signi cantly altered in squamous cell carcinomas across multiple organ sites, which were drivers of carcinogenesis [21]. These altered regulators in EC might be associated with development of second primary malignancy which was similar to EC in histological subtypes.…”

Section: Patient and Tumor Characteristicsmentioning

confidence: 95%

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

Gao

Qiu

et al. 2020

Preprint

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Background: The present study aimed to assess the incidence, characteristics, and survival of secondary primary lung cancer after primary esophageal cancer (EC-LC). Methods: The patients with esophageal cancer (EC) who developed SPLC and patients with first primary lung cancer (LC-1) were retrospectively reviewed in the Surveillance, Epidemiology, and End Results 18 registries covering 2000 to 2016. The risk of secondary primary lung cancer using standardized incidence ratio (SIR) was calculated among patients with EC. Overall survival and characteristics were compared between patients with EC-LC and patients with LC-1.Results: In comparison with the general population, the patients with EC had a higher risk for developing secondary primary lung cancer (SIR =1.86, 95% confidence interval (CI): 1.69-2.05). There was a significant difference with regard to the year of diagnosis, sex, grade and stage between the secondary primary lung squamous carcinoma after EC (EC-LUSC) and first primary lung squamous carcinoma (LUSC-1) patients. A statistically significant difference with respect to race, sex, age, year, grade and stage was found between the secondary primary lung adenocarcinoma after EC (EC-LUAD) and first primary lung adenocarcinoma (LUAD-1) patients. A history of EC was found to be an independent risk factor of death for lung squamous carcinoma and lung adenocarcinoma patients in localized stage based on multivariate Cox regression analysis, propensity score-matching analysis and multiple imputation.Conclusion: There is a significantly increased risk of secondary primary lung cancer in EC survivors and a history of EC adversely affects overall survival in individuals who subsequently develop localized EC-LUSC and EC-LUAD. Clinicians should moderately strengthen lung tissue protection during the management of EC patients.

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Unraveling cancer lineage drivers in squamous cell carcinomas

Cited by 24 publications

References 419 publications

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Primary nonkeratinizing squamous cell carcinoma of the scapular bone: A case report

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

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