Unraveling the estrogen receptor (er) genes in Atlantic salmon (Salmo salar) reveals expression differences between the two adult life stages but little impact from polychlorinated biphenyl (PCB) load

Nikoleris, Lina; Hansson, Maria

doi:10.1016/j.mce.2014.11.009

Cited by 11 publications

(5 citation statements)

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“…Lower expression of er might also result from reallocation of energy resources away from reproduction and towards tolerance mechanism, highlighted in a study of Xie and Klerks [68]. Moreover, the level of er expression highly depends on the stage of reproductive cycle of fish [66,67]. Finally, decrease in the expression of genes coding different ER subtypes in fish liver after exposure to synthetic ligands was also reported by other authors [69].…”

Section: Adaptive Responses In a Brama Exposed To Chemical Stressmentioning

confidence: 64%

“…Significant discrepancies that can occur between in vitro screening assays and the induction of estrogenic biomarkers in fish were explained by Yost et al [66] by the specific involvement of different ER subtypes in the teleost estrogenic response. Moreover, it is possible that potential xenoestrogens are deactivated through biotransformation processes in fish (a process that can't be observed in the in vitro assays), limiting their estrogenic effects, which, together with specific 'cocktail' effects in vivo could provide explanation for such result [67]. Lower expression of er might also result from reallocation of energy resources away from reproduction and towards tolerance mechanism, highlighted in a study of Xie and Klerks [68].…”

Section: Adaptive Responses In a Brama Exposed To Chemical Stressmentioning

confidence: 99%

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Fish biomarkers from a different perspective: evidence of adaptive strategy of Abramis brama (L.) to chemical stress

et al. 2020

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Background: A prerequisite for long-term survival of populations under multi-stress conditions is their capacity to set up efficient adaptive strategies. However, changes in the activity of molecular biomarkers have been for decades considered as early signals of the deterioration of the fish health and evidence of stress-related adverse biological effects. The aim of this study was to show that such changes actually represent adaptive response of fish to chemical stress. Gene expression and enzyme activity level in liver and brain of specimens from two populations of Abramis brama from contrasted habitats (nature reserve and urban) were examined. Selected parameters included biomarkers of general stress, antioxidative defence, xenobiotic metabolism, endocrine disruption, glucose homeostasis, iron homeostasis, and neurotoxicity. Results: Exposure of A. brama population from urban area to chemical stress was confirmed by assessment of chronic toxic pressure at fish habitats using Toxic Unit approach. The most pronounced response to chemical stress is observed through the activation of antioxidative defence mechanisms in brain and liver at gene and enzyme activity level, high biotransformation capacity of liver, and activation of mechanisms that will meet energy demands and compensate for the metabolic costs of the response to toxicants (higher expression of genes related to glucose homeostasis in the exposed population). Higher hepatosomatic index in the exposed population implies liver hypertrophy due to increased functional load caused by pollution. Body condition factors indicate good overall condition of both fish populations and confirm high efficacy of mobilized adaptation mechanisms in the exposed population. Conclusions: The study provided the first data on basal expression of a number of genes in A. brama, potentially valuable for biomonitoring studies in absence of clear pollution gradient and/or reference sites (conditions). The study highlights importance of newly identified roles of various genes and proteins, typically considered as biomarkers of effects, and shows that changes in these parameters do not necessarily indicate the deterioration of the fish health. Such changes should be considered as adaptive response to chemical stress, rather than direct proof of ecological impact of pollution in situ.

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Section: Adaptive Responses In a Brama Exposed To Chemical Stressmentioning

confidence: 64%

Section: Adaptive Responses In a Brama Exposed To Chemical Stressmentioning

confidence: 99%

Fish biomarkers from a different perspective: evidence of adaptive strategy of Abramis brama (L.) to chemical stress

et al. 2020

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“…Such is the case with gilthead seabream (Sparus aurata L.) (Pinto et al, 2006), Atlantic croaker (Micropogonias undulatus) (Hawkins et al, 2000), zebrafish (Danio rerio) (Menuet et al, 2002), goldfish (Carassius auratus) (Ma et al, 2000), European sea bass (Dicentrarchus labrax) (Halm et al, 2004), common carp (Cyprinus carpio) (Katsu et al, 2013), medaka (Oryzias latipes) (Chakraborty et al, 2011), and European eel (Anguilla anguilla) (Lafont et al, 2016). Moreover, a second form of esr1 (ERα2) has been described in rainbow trout (Oncorhynchus mykiss) (Nagler et al, 2007), Atlantic salmon (Salmon salar) (Nikoleris and Hansson, 2015) and in some cyprinid species such as Spinibarbus denticulatus (Zhu et al, 2008) and Pengze crucian carp (Carassius auratus var. pengze, Pcc) (Zheng et al, 2013); so that these species have four different ERs isotypes, two ERα and two ERβ.…”

Section: Ers In Fishmentioning

confidence: 99%

Role of estrogens in fish immunity with special emphasis on GPER1

Cabas

Chaves-Pozo

Mulero

et al. 2018

Developmental & Comparative Immunology

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“…PCBs and PBDEs are recognized as endocrine disruptors that can disrupt the homeostasis of sex hormones. − The mechanisms for this disruption include controlling the conversion of testosterone (Tr) and estradiol (E2); − altering mRNA expression of the progesterone receptor, androgen receptor, and estrogen receptor; − and further interrupting the sex hormones via the response of the hypothalamus–pituitary–gonadal–liver axis. − …”

Section: Introductionmentioning

confidence: 99%

Human Sex Hormone Disrupting Effects of New Flame Retardants and Their Interactions with Polychlorinated Biphenyls, Polybrominated Diphenyl Ethers, a Case Study in South China

Guo

Pan

et al. 2018

Environ. Sci. Technol.

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Even though sex hormone disrupting effects of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are widely understood, similar effects associated with new flame retardants (NFRs) have not been so well studied. This study aimed to explore the sex hormone disruption of NFRs and their interactions with PCBs and PBDEs through the conduct of an ecological study in an e-waste dismantling and control region in South China. Questionnaires and blood samples were collected from local adult residents. Results of generalized additive model and linear regression analyses indicate that several species of NFRs showed similar disrupting effects with PBDE congeners on female follicle-stimulating hormone (FSH) and male testosterone. Judged by the curved shape and statistical significance, ΣNFR (sum of 8 species of NFRs) showed stronger disrupting effects on male testosterone and female FSH compared to ΣPBDE (sum of 13 congeners of PBDEs). The interactions induced by NFRs complicated the original sex hormone disruption led by PCBs and PBDEs. The disrupting effects and interactions induced by NFRs decreased female FSH levels in the exposed group. Comprehensive evaluation is needed to provide the evidence base for judging the health risks arising from the increased usage of NFRs.

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Unraveling the estrogen receptor (er) genes in Atlantic salmon (Salmo salar) reveals expression differences between the two adult life stages but little impact from polychlorinated biphenyl (PCB) load

Cited by 11 publications

References 60 publications

Fish biomarkers from a different perspective: evidence of adaptive strategy of Abramis brama (L.) to chemical stress

Fish biomarkers from a different perspective: evidence of adaptive strategy of Abramis brama (L.) to chemical stress

Role of estrogens in fish immunity with special emphasis on GPER1

Human Sex Hormone Disrupting Effects of New Flame Retardants and Their Interactions with Polychlorinated Biphenyls, Polybrominated Diphenyl Ethers, a Case Study in South China

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