Unraveling the Molecular Mechanisms of Fructus Anisi Stellati as a Remedy for Infantile Colic by Network Pharmacology

Li, Xingyu; Xu, Yan

doi:10.1155/2020/9210304

Cited by 6 publications

(6 citation statements)

References 37 publications

(17 reference statements)

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“…This is attributed to its demonstrated effectiveness in antimicrobial, antifungal, and antioxidant activities (Benmalek et al., 2013; Chouksey & Sharma, 2010). Star anise reportedly is utilized in treatment of various diseases, such as infantile colic and metastatic cancer (Li & Xu, 2020; Shu et al., 2010). Additionally, a promising COVID‐19 main protease inhibitor was identified from star anise (Tripathi et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Apart from its food value using in condiment, star anise holds a crucial position in traditional medicinal resources and demonstrates expectorant and spasmolytic activities (Sharafan et al., 2022; Wang et al., 2011). Reportedly, star anise is widely used to treat abdominal pain, bloating, and infantile colic (Kamoun et al., 2019; Li & Xu, 2020). In addition, star anise has strong antiviral activities, particularly for influenza virus A/Puerto Rico/8/34 H1N1 (PR8) (Wu et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

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Exploring the pharmacological mechanisms of star anise against COVID‐19 using network pharmacology and molecular docking

Li,

Gao,

Liu

et al. 2024

Food Safety and Health

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Traditional Chinese Medicine (TCM) has exhibited promising preventive and therapeutic attributes against COVID‐19. This study aims to investigate the active constituents within star anise and elucidate their mechanisms in combatting COVID‐19, employing a combination of GC‐MS analysis, network pharmacology, and molecular docking techniques. Various extraction methods were employed to obtain star anise compounds, which were subsequently subjected to GC‐MS analysis. A comprehensive star anise and COVID‐19‐related genomic network was established through Swiss Target Prediction and disease‐gene databases. Network pharmacology analysis unveiled the significant prominence of common core targets, namely TLR4, PTGS2, RELA, and ESR1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that star anise may exert its preventive effects against COVID‐19 by modulating immune responses, apoptosis, and viral infections. Molecular docking investigations provided compelling evidence of substantial interactions between the active compounds found in star anise and the key target proteins. In summary, this work has the potential to offer new avenues and a theoretical foundation for a more in‐depth understanding of the multicomponents, multitarget, and multipathway properties of star anise in preventing COVID‐19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the pharmacological mechanisms of star anise against COVID‐19 using network pharmacology and molecular docking

Li,

Gao,

Liu

et al. 2024

Food Safety and Health

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“…The known disease-related targets were retrieved from the Online Mendelian Inheritance in Man (OMIM; http://omim.org/ ) ( 34 ), GeneCards ( https://www.genecards.org/ ) ( 35 ), and a database of gene-disease associations (DisGeNet; https://www.disgenet.org/ ) ( 36 ) databases using keywords of “gastrointestinal bleeding” and “gastrointestinal hemorrhage”. A higher score indicated a stronger interaction, so the targets with a relevance score >5 in GeneCards were collected ( 37 ). All target names were converted into gene symbols using UniProt databases, with the species limited to “ Homo sapiens .” We gathered the genes of the active components from Gardenia jasminoides and gastrointestinal hemorrhage-related targets to determine the overlapping target genes using a Venn diagram.…”

Section: Methodsmentioning

confidence: 99%

“…org/) (35), and a database of gene-disease associations (DisGeNet; https://www.disgenet.org/) (36) databases using keywords of "gastrointestinal bleeding" and "gastrointestinal hemorrhage". A higher score indicated a stronger interaction, so the targets with a relevance score >5 in GeneCards were collected (37). All target names were converted into gene symbols using UniProt databases, with the species limited to "Homo sapiens."…”

Section: Collection Of Disease Targetsmentioning

confidence: 99%

Investigation of the hemostatic mechanism of Gardeniae fructus Praeparatus based on pharmacological evaluation and network pharmacology

Zheng¹,

Wang²,

Xia³

et al. 2022

Ann Transl Med

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Background: As documented in the Chinese Pharmacopoeia, Gardeniae fructus Praeparatus (GFP) can cool the blood during hemostasis and treat various internal hemorrhagic diseases. However, the underlying mechanisms are not yet well understood. This work was designed to decipher the possible mechanism by which GFP prevents hemorrhage. The integration of pharmacodynamics-based and bioinformatics-based methods provided evidence to support the clinical effects of GFP in treating bleeding.Methods: Using ultra-performance liquid chromatography (UPLC) analysis, we quantified the main active ingredients for a preliminary quality assessment of GFP. The pharmacology study was conducted to confirm the essential antihemorrhagic effects of GFP. A rat model of ethanol-induced gastric hemorrhage was established and was followed by intervention with GFP in low, middle, and high doses (4.5, 9, 18 g/kg).Gastric tissues were harvested for macroscopic and histological evaluation of lesions. The contents of thromboxane B2 (TXB 2 ) and 6-keto-prostaglandin-F1α (6-keto-PGF 1α ) in the serum were determined.Additionally, network pharmacology was proposed to illuminate the potential mechanisms. Following the collection of GFP compositions, the compound-and hemorrhage-related targets were retrieved from public databases. The protein-protein interaction (PPI), gene ontology, pathways analysis, and molecular docking were performed for targets of GFP in gastrointestinal bleeding. Results:The study found ten main active ingredients that could be used for quality control of GFP.Importantly, the middle and high doses of GFP were found to promote the healing of gastric bleeding.The content of 6-keto-PGF 1α was significantly degraded in the middle and high treated groups (P<0.05).The level of TXB 2 was augmented by a middle (P<0.05) and high dose of GFP. Further, we constructed the network of candidate ingredients and hemorrhage-related targets. Pathway analysis predicted the mechanisms associated with interleukin 4 and interleukin 13 signaling and platelet activation. PPI analysis identified subnetworks with biological functions and also sifted hub targets that affected the antihemorrhagic progress. The candidate proteins had a good binding force with major components.Conclusions: GFP exhibits a promising effect in ameliorating bleeding, with the relevant molecular mechanisms possibly being related to the regulation of the immune system and platelet activation. Therefore, GFP can potentially exert a protective effect on gastrointestinal bleeding in clinic.

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“…The use of ASF in treating various infections and diseases is practiced in various regions, including Asia and North America [ 65 ]. It is reported to possess antimicrobial, antiviral, and antioxidant properties [ 66 ].…”

Section: An Example Of Tcm: Asf and Its Activity Against Gcmentioning

confidence: 99%

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

Khan

Shamim

2022

Evidence-Based Complementary and Alternative Medicine

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Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F. (Chinese star anise), which is native to many countries, and is a significant Chinese medicinal herb. Gastric cancer (GC) is one of the major fatal types of cancers with multiple stages and a poor prognosis. The present review aims to discuss the bioactive properties of ASF and its phytocompounds against GC, with a particular insight into the molecular mechanisms and signaling pathways involved in its anti-GC mechanism. Furthermore, it highlights the potential mechanism of action of major phytocompounds of ASF against GC. Clinical studies (in vitro and in vivo) regarding the action of ASF and its major bioactive compounds such as quercetin, luteolin, kaempferol, d-limonene, and honokiol against GC were reviewed. For this review, search of literature was performed in Science, PubMed, Google Scholar, Web of Science, and Scopus related to ASF and its phytocompounds, from which only relevant studies were chosen. Major bioactive compounds of ASF and their extracts have proven to be effective against GC due to the mechanistic action of these compounds involving signaling pathways that target cancer cell apoptosis, proliferation, and tumor metastasis in GC cells. Existing reports of these compounds and their combinatory effects with other modern anticancer agents have also been reviewed. From its traditional use to its role as an anticancer agent, ASF and its bioactive phytocompounds have been observed to be effective in modern research, specifically against GC. However, further studies are required for the identification of molecular targets and pharmacokinetic potential and for the formulation of anti-GC drugs.

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Unraveling the Molecular Mechanisms of Fructus Anisi Stellati as a Remedy for Infantile Colic by Network Pharmacology

Cited by 6 publications

References 37 publications

Exploring the pharmacological mechanisms of star anise against COVID‐19 using network pharmacology and molecular docking

Exploring the pharmacological mechanisms of star anise against COVID‐19 using network pharmacology and molecular docking

Investigation of the hemostatic mechanism of Gardeniae fructus Praeparatus based on pharmacological evaluation and network pharmacology

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

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