Unraveling the Role of Angiogenesis in Cancer Ecosystems

Abstract

Activation of the tumor and stromal cell-driven angiogenic program is one of the first requirements in the tumor ecosystem for growth and dissemination. The understanding of the dynamic angiogenic tumor ecosystem has rapidly evolved over the last decades. Beginning with the canonical sprouting angiogenesis, followed by vasculogenesis and intussusception, and finishing with vasculogenic mimicry, the need for different neovascularization mechanisms is further explored. In addition, an overview of the orchestration of angiogenesis within the tumor ecosystem cellular and molecular components is provided. Clinical evidence has demonstrated the effectiveness of traditional vessel-directed antiangiogenics, stressing on the important role of angiogenesis in tumor establishment, dissemination, and growth. Particular focus is placed on the interaction between tumor cells and their surrounding ecosystem, which is now regarded as a promising target for the development of new antiangiogenics.

Effect of anlotinib as a third‐ or further‐line therapy in advanced non‐small cell lung cancer patients with different histologic types: Subgroup analysis in the ALTER0303 trial

“…Angiogenesis is very important for several aspects of tumor development, including tumor growth, invasion, and metastasis . Therefore, antiangiogenesis therapy plays an important role in oncotherapy.…”

Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

“…Spectra were measured in D2O-buffer (pH 6.0) using TMSP as standard, residual water signal has been removed. (14), caffeic acid (15), trigonelline (16), formic acid (17). Spectra were measured in D 2 O-buffer (pH 6.0) using TMSP as standard, residual water signal has been removed.…”

“…Next to common targets for tumor therapy, such as cell cycle inhibitors or proapoptotic agents, there are often angiogenesis modulators, especially in combined treatments [13]. The solid tumors, in fact, require an increased blood supply to support their growth, thus, angiogenesis is critical for the initiation, growth, and metastasis of these tumors [14].…”

Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model

“…This ubiquitous phenomenon in health and disease of higher organisms [1], plays a crucial role in the natural processes of organ growth and repair [2], wound healing [3], or inflammation [4]. Angiogenesis imbalance contributes to numerous malignant, inflammatory, ischaemic, infectious, and immune diseases [2,5], such as cancer [6][7][8][9][10], rheumatoid arthritis [11], neovascular age-related macular degeneration [12], endometriosis [13,14], and diabetes [15].…”