Unraveling the Structure Transition and Peroxidase Mimic Activity of Copper Sites over Atomically Dispersed Copper‐Doped Carbonized Polymer Dots

Abstract

The lack of systematic structural resolution makes it difficult to build specific transition-metal-atom-doped carbonized polymer dots (TMA-doped CPDs). Herein, the structure-activity relationship between Cu atoms and CPDs was evaluated by studying the peroxidase-like properties of GluÀ CuÀ CPDs prepared by using copper glutamate (Glu) with a CuÀ N 2 O 2 initial structure. The results showed that the Cu atoms bound to GluÀ CuÀ CPDs in the form of CuÀ N 2 C 2 , indicating that CuÀ O bonds changed into CuÀ C bonds under hydrothermal conditions. This phenomenon was also observed in other copper-doped CPDs. Moreover, the carboxyl and amino groups content decreased after copper-atom doping. Theoretical calculations revealed a dual-site catalytic mechanism for catalyzing H 2 O 2 . The detection of intracellular H 2 O 2 suggested their application prospects. Our study provides an in-depth understanding of the formation and catalytic mechanism of TMA-doped-CPDs, allowing for the generation specific TMA-doped-CPDs.

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

“…The lower binding energies compared with the standard peak of CoO (779.7 eV) suggest the existence of Co–N bonds in Co-Lvx-CDs. 28…”

“…The lower binding energies compared with the standard peak of CoO (779.7 eV) suggest the existence of Co-N bonds in Co-Lvx-CDs. 28 Moreover, the Co-Lvx-CDs exhibited inherent photoluminescence and emitted strong blue-green fluorescence. The Co-Lvx-CDs and Lvx-CDs had absorption peaks at 340 nm and 361 nm, respectively, which originated from the carbon core p-p* transition (Fig.…”

“…27 Jiang et al reported copper-doped CDs and proposed a dual-site catalytic mechanism, demonstrating that the coordination of Cu-N 2 C 2 provided the active sites for POD and that this can be extended to other transition metals. 28 Theoretically, CDs can be endowed with intrinsic antibacterial activity and enzyme-like activity by selecting specific carbon sources and metal sources, and this ambidextrous approach can finally achieve enhanced antibacterial capabilities.…”

Lignocellulosic Biomass‐Based Carbon Dots: Synthesis Processes, Properties, and Applications

“…Other studies have reported similar findings, highlighting the effectiveness of metal element doping in modifying the properties of LC-CDs. [98,145,149] Among these doping methods, the N-element doping strategy is particularly favored due to the diverse forms of N-element doping observed in CDs. N-element doping can occur in various configurations, including sp 2 -hybridized C═N─C, porphyrin C─N─C, as well as amino N and quaternary N groups, which exhibit distinct hybridization behaviors with carbon (C) atoms.…”

Single‐atom metal‐nitrogen‐carbon catalysts energize single molecule detection for biosensing

“…In particular, SACs with high catalytic activity and molecule sensitivity could achieve the detection of specific single molecules through various regulations such as by modulating the LCE and the metal–support interaction 23 . For instance, Cu‐N x O y ‐C with different nitrogen coordination numbers has been reported recently to unveil the influence of LCE on H 2 O 2 detection 24 . Therefore, SACs can be regarded as among the most promising nanozymes for single‐molecule detections.…”