Unravelling the Impact of Calcium Content on the Bioactivity of Sol–Gel-Derived Bioactive Glass Nanoparticles

Abstract

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Protein Adsorption on SiO2-CaO Bioactive Glass Nanoparticles with Controllable Ca Content

“…However, the actual concentration of incorporated CaO was lower than the nominal CaO concentration in these particles. Such a gap between nominal and actual compositions of BGNs has also been reported in the literature [7][8][9]. Given the concentration-dependent therapeutic effects of biologically active ions, precise control over the amount of incorporated CaO is crucial as it is directly related to the ion-released behavior.…”

“…BGNs are usually synthesized using sol-gel processing, a wet chemistry route involving the hydrolysis and condensation of alkoxide precursors (typically tetraethyl orthosilicate) [1]. By varying the sol-gel processing parameters (e.g., the molar ratio of precursors and catalysts), the size, chemical composition, and textural properties of BGNs can be controlled [7][8][9][10][11]. The composition significantly influences the structure and properties of glasses [12].…”

“…The composition significantly influences the structure and properties of glasses [12]. Particularly, calcium (Ca) is an essential component that distinguishes BGNs from silica nanoparticles, as Ca significantly contributes to the formation of hydroxyapatite (HA) that can bond to bone tissues [7]. The released Ca 2+ ions can also induce favorable cell activities (e.g., proliferation, osteogenic differentiation, extracellular matrix mineralization) involved in bone regeneration [13,14].…”

“…Glass composition can also affect protein adsorption on BGs [15]. It is known that the content of CaO in BGNs can affect their degradation and bioactivity [7,8,19]. However, the influence of CaO content in BGNs on protein adsorption has not been investigated yet.…”

Elaboration of Superparamagnetic and Bioactive Multicore–Shell Nanoparticles (γ-Fe2O3@SiO2-CaO): A Promising Material for Bone Cancer Treatment

“…A closer inspection to the XRD pattern of Figure 8a shows new Bragg reflections characteristic of hydroxyapatite (HAp, JCPDS 09-0432). 38 Furthermore, the presence of maghemite NPs peaks suggests their immobilization inside the heterostructures or within the apatite phase. While the FTIR spectra of the raw heterostructured NPs only shows absorption bands of the silica network, the FTIR spectra of the particles immersed in SBF clearly shows the appearance of 2 new bands respectively at 564 cm -1 and 604 cm -1 (Figure 8b) which can be assigned to HAp.…”