Unravelling the molecular interaction of diselenodipropionic acid (DSePA) with human serum albumin (HSA)

Abstract

Diselenodipropionic acid (DSePA), a selenocystine derivative, has emerged as a promising pharmacologically active organoselenium compound. In order to fully utilize its activity, there is a need to understand its transport...

Noncovalent interactions of antitumor cycloplatinated complexes containing trifluoroacetate ligands as the leaving group with bovine serum albumin. Implications for drug design

“…The results of CD spectra, reported in Table 3, indicate that during the interaction with Pt(II) compounds, the proportion of a-helix decreases in the secondary structures of BSA with an increase in the fraction of random coils and b-sheets. 13,72 Moreover, the change in the conformation of the BSA structure by 2 is more pronounced than that by 1, which is in agreement with the larger binding constant of 2 compared to that of 1.…”