Unravelling the relationship between serum 25-hydroxyvitamin D levels and trabecular bone score in U.S. adults

Yang, Shih‐Wei; Lin, Yu‐Sheng; Cheng, Yung-Wen; Chen, Yuan‐Yuei; Chen, Wei‐Liang

doi:10.20452/pamw.16311

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Participants with history of vitamin D supplementation surprisingly had lower TBS compared to those who did not receive vitamin D in our study, which was seemingly contradicting preceding studies which showed that vitamin D deficiency was associated with lower TBS [ 35 36 ]. Participants with history of vitamin D supplementation in our study might indeed, had lower serum 25-hydroxyvitamin D level to begin with, and therefore, had vitamin D prescribed.…”

Section: Discussioncontrasting

confidence: 99%

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Therdyothin

Amphansap

2022

J Menopausal Med

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Objectives To compare the trabecular bone score (TBS) between Thai postmenopausal women with and without major osteoporotic fracture, and to determine whether TBS is associated with fracture risk. Methods All postmenopausal women sent for dual-energy X-ray absorptiometry (DXA) at the Police General Hospital were retrospectively recruited. The hospital’s online database and radiographs were reviewed to collect information on underlying disease, medication, previous fractures, bone mineral density, and trabecular bone score. Patients with anti-osteoporotic medication use, skeletal malignancy, fracture from high-energy trauma, and uninterpretable DXA images were excluded. Results A total of 407 Thai postmenopausal women were enrolled. They were divided into 292 women without fractures and 115 women with major osteoporotic fractures. The fracture group was older (73.36 ± 9.95 vs. 66.00 ± 8.58, P < 0.001) and had lower serum 25-hydroxyvitamin D levels (23.28 ± 9.09 vs. 26.44 ± 9.20, P = 0.023). The mean TBS was lower in the fracture group, compared to the non-fracture group (1.244 ± 0.101 vs. 1.272 ± 0.099, P = 0.011). The subgroup analysis resulted in noticeably lower TBS in spine fracture, but not other fracture sites. The odds ratio of fracture was 1.355 ( P = 0.013) for a decrease in one standard deviation of TBS. Conclusions TBS was significantly lower in postmenopausal women having fractures with an odd ratio of 1.355 ( P = 0.013) per SD decrease in TBS. Categorizing by fracture sites, TBS was only found to be noticeably lower in the lumbar spine despite similar lumbar spine bone mineral density.

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Section: Discussioncontrasting

confidence: 99%

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Therdyothin

Amphansap

2022

J Menopausal Med

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“…VD was first described in 1920 [11] and interest in it has not waned since then [12,13]. The rationale for exploring its association with CVD was the discovery of VD receptors' expression throughout the circulatory system [14] including cardiomyocytes [15] and human coronary artery smooth cells [16].…”

Section: Introductionmentioning

confidence: 99%

Relationship of vitamin D deficiency to cardiovascular disease and glycemic control in patients with type 2 diabetes mellitus: The Silesia Diabetes-Heart Project

Kwiendacz¹,

Nabrdalik²,

Wijata³

et al. 2023

Polish Archives of Internal Medicine

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There is no consistency in the literature between observational and interventional studies regarding vitamin D deficiency (VDD) and both cardiovascular disease (CVD) and glycemic control of diabetes. The outcomes of this observational study among Polish patients with type 2 diabetes revealed that 36% of participants have VDD. We did not find an association between VDD and CVD and the difference between groups in glycemic control of diabetes was insignificant.However we found that patients with VDD had higher prevalence of treatment with sodiumglucose co-transporter-2 inhibitors (SGLT-2i) compared to patients with vitamin D (VD) concentrations within the reference range, which is, to the best of our knowledge, a novel finding. This is of high importance given the concerns that SGLT-2i may possibly affect the bone turnover through a negative influence on VD concentration.

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“…Higher values of TBS indicate a better microarchitecture, whereas lower values indicate a degraded microarchitecture. In addition, TBS's prediction of fracture risk has been widely reported in cross-sectional, prospective and longitudinal studies, and has been endorsed by medical societies of bone eld (IOF, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and the ISCD) 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study

Zhao,

Li,

Tian

et al. 2023

Preprint

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Background: The TBS is a new method for clinicians to assess bone quality. It is directly related to the mechanical strength of bone and helps predict fracture risk. The present analysis aimed to the associations between serum PTH level and TBS by analyzing data from the National Health and Nutrition Examination Survey (NHANES). Methods. A total of 3516 participants from the NHANES 2005–2006 were included in this cross-sectional analysis. Independent variables were serum PTH, which a key role in mineral homeostasis and bone metabolism. Outcome variable was TBS. The associations of serum PTH levels with TBS was examined using multivariable linear regression models. Results. After adjusting for covariates, there was a negative association between the serum PTH level and TBS (β= -0.0034; 95% confidence interval, -0.0050– -0.0017). However, in the subgroup analysis stratified by gender, race, and age, this association became negative only in Non-Hispanic White (β = − 0.0047, 95% CI: − 0.0071– − 0.0048) and young people (age＜60) (β = − 0.0036, 95% CI: -0.0057, -0.0016). In addition, the association of serum PTH with TBS was an inverted U-shaped curve, with a point of inflection a 6.71 pmol/L. Conclusion: This study showed that serum PTH levels were negative associated with TBS. This finding indicated that maintaining PTH at low levels may be beneficial to bone health, especially for young non-Hispanic white.

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Unravelling the relationship between serum 25-hydroxyvitamin D levels and trabecular bone score in U.S. adults

Cited by 5 publications

References 28 publications

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Relationship of vitamin D deficiency to cardiovascular disease and glycemic control in patients with type 2 diabetes mellitus: The Silesia Diabetes-Heart Project

Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study

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