Unravelling the role of obesity and lipids during tumor progression

Zhao, Junzhe; Lee, Keene; Toh, Han Chong; Lam, Kong Peng; Neo, Shi Yong

doi:10.3389/fphar.2023.1163160

Cited by 3 publications

(1 citation statement)

References 169 publications

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“…In addition, excess fatty acids (FAs) in the body can also stimulate ER stress, inducing hepatocellular damage, liver fibrosis and cirrhosis, and accelerating the development of hepatocellular carcinoma [ 84 ]. While combining conventional immune checkpoint inhibitors with mitochondrial fatty acid transporter inhibitors (e.g., etomoxir) can reverse the metabolic reprogramming of DC cells and restore the immune killing effect of T cells, which is an ideal medicine to target abnormal lipid metabolism [ 85 ]. Furthermore, it has been revealed that circ-DB is highly expressed in HCC patients with a high percentage of body fat and is associated with poor prognosis, suggesting that circ-DB may promote HCC progression through fatty acid synthesis (FAS), providing a new therapeutic target for targeting tumor lipid metabolism [ 86 ].…”

Section: Tumor-derived Exosomal Circrnas In Tumor Progressionmentioning

confidence: 99%

Exosomal circRNA: emerging insights into cancer progression and clinical application potential

et al. 2023

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Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regulating critical aspects of cancer progression including immune escape, tumor angiogenesis, metabolism, drug resistance, proliferation and metastasis. Interestingly, microenvironment cells have new findings in influencing tumor progression and immune escape mediated by the release of exosomal circRNA. Given the intrinsic stability, abundance, and broad distribution of exosomal circRNAs, they represent excellent diagnostic and prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up new possibilities for cancer therapy, potentially bolstered by nanoparticles or plant exosome delivery strategies. In this review, we summarize the functions and underlying mechanisms of tumor cell and non-tumor cell-derived exosomal circRNAs in cancer progression, with a special focus on their roles in tumor immunity and metabolism. Finally, we examine the potential application of exosomal circRNAs as diagnostic biomarkers and therapeutic targets, highlighting their promise for clinical use.

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Section: Tumor-derived Exosomal Circrnas In Tumor Progressionmentioning

confidence: 99%

Exosomal circRNA: emerging insights into cancer progression and clinical application potential

et al. 2023

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Obesity, white adipose tissue and cancer

Solsona‐Vilarrasa,

Vousden

2024

The FEBS Journal

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White adipose tissue (WAT) is crucial for whole‐body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet the body's requirements, dysfunctional WAT in conditions like obesity is characterized by excessive tissue expansion, alterations in lipid homeostasis, inflammation, hypoxia, and fibrosis. Obesity is strongly associated with an increased risk of numerous cancers, with obesity‐induced WAT dysfunction influencing cancer development through various mechanisms involving both systemic and local interactions between adipose tissue and tumors. Unhealthy obese WAT affects circulating levels of free fatty acids and factors like leptin, adiponectin, and insulin, altering systemic lipid metabolism and inducing inflammation that supports tumor growth. Similar mechanisms are observed locally in an adipose‐rich tumor microenvironment (TME), where WAT cells can also trigger extracellular matrix remodeling, thereby enhancing the TME's ability to promote tumor growth. Moreover, tumors reciprocally interact with WAT, creating a bidirectional communication that further enhances tumorigenesis. This review focuses on the complex interplay between obesity, WAT dysfunction, and primary tumor growth, highlighting potential targets for therapeutic intervention.

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High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region

Fernandes,

Harris,

Zamalloa

et al. 2024

IJMS

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The global burden of liver cancer is increasing. Timely diagnosis is important for optimising the limited available treatment options. Understanding the metabolic consequences of hepatocellular carcinoma (HCC) may lead to more effective treatment options. We aimed to document metabolite differences between HCC and matched surrounding tissues of varying aetiology, obtained at the time of liver resection, and to interpret metabolite changes with clinical findings. High-resolution magic angle spinning nuclear magnetic resonance (HRMAS-NMR) spectroscopy analyses of N = 10 paired HCC and surrounding non-tumour liver tissue samples were undertaken. There were marked HRMAS-NMR differences in lipid levels in HCC tissue compared to matched surrounding tissue and more subtle changes in low-molecular-weight metabolites, particularly when adjusting for patient-specific variability. Differences in lipid-CH3, lipid-CH2, formate, and acetate levels were of particular interest. The obvious differences in lipid content highlight the intricate interplay between metabolic adaptations and cancer cell survival in the complex microenvironment of liver cancer. Differences in formate and acetate might relate to bacterial metabolites. Therefore, documentation of metabolites in HCC tissue according to histology findings in patients is of interest for personalised medicine approaches and for tailoring targeted treatment strategies.

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Unravelling the role of obesity and lipids during tumor progression

Cited by 3 publications

References 169 publications

Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Obesity, white adipose tissue and cancer

High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region

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