Unrelated bone marrow as a source of Bacillus cereus causing septic shock

Microbial contamination of cord blood stem cells

“…These four micro‐organisms are potential pathogens, and the presence of even low numbers of potentially pathogenic micro‐organisms is a criterion for discarding units from our bank. A recent report of septic shock caused by Bacillus cereus after unrelated bone marrow (BM) transplantation highlights the implications of pathogenic bacteria in stem cell therapy [17]. The potential risks of not detecting pathogens in culture where the sample volumes are low should be reviewed.…”

Sterility testing of hematopoietic progenitor cell products: a single‐institution series of culture‐positive rates and successful infusion of culture‐positive products

“…Clinical course the same as recipients of noncontaminated products. de Medeiros 22 1 Septic shock. Culture-positive after infusion.…”

Successful treatment of Bacillus cereus meningitis following allogenic stem cell transplantation

“…Another report published by Medeiros et al. (11) describes the case of septic shock caused by B. cereus contaminated allogenic bone marrow, which was transported from the United States to Brazil. The patient did not experience any CNS infection and survived.…”

“…Sanfructuso et al (10) reported the case of B. cereus septicemia-associated rhabdomyolysis in a woman 215 days after autologous SCT because of a relapsed HodgkinÔs disease. Another report published by Medeiros et al (11) describes the case of septic shock caused by B. cereus contaminated allogenic bone marrow, which was transported from the United States to Brazil. The patient did not experience any CNS infection and survived.…”