Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention

Abstract

The likelihood of rupture of unruptured intracranial aneurysms that were less than 10 mm in diameter was exceedingly low among patients in group 1 and was substantially higher among those in group 2. The risk of morbidity and mortality related to surgery greatly exceeded the 7.5-year risk of rupture among patients in group 1 with unruptured intracranial aneurysms smaller than 10 mm in diameter.

Lymphoma and Leukemia Cells Possess Fractal Dimensions That Correlate with Their Biological Features

“…Sedivy et al [11] previously demonstrated that human cells have fractal dimensions in dysplastic and control nuclei derived from uterus cervix cone biopsies. Thus, our findings are consistent with previous reports [11, 15]. It is worth pointing out that there was a correlation between the fractal dimension and the aggressiveness of the lymphoma, i.e.…”

“…In a related study, Adam et al [15] calculated the fractal dimension of nuclear chromatin (using the Minkowski-Bouligand method extended to three dimensions) of blasts derived from 28 patients with acute B lymphoblastic leukemia and assessed its prognostic importance. While fractal dimension had no prognostic importance in that study, goodness of fit of the fractal dimension, estimated by R 2 , correlated with prolonged survival.…”

Quality of Life after Treatment of Unruptured Intracranial Aneurysms by Neurosurgical Clipping or by Embolisation with Coils

“…Treatment can be done by neurosurgical clipping and by coil embolisation. In systematic reviews of published series, surgical treatment was associated with a permanent morbidity of 11% and a mortality of 3% [6, 7], and coil embolisation with a rate of permanent procedural complications of 7% [8]. …”

Clinical guidelines for treatment of unruptured asymptomatic brain aneurysms

“…Показа-но, что разорвавшиеся аневризмы имеют большие размеры по сравнению с неразорвавшимися [28,59]. При этом единых представлений о критическом размере нет.…”

“…При этом единых представлений о критическом размере нет. По одним данным, повышенный риск разрыва имеют аневризмы более 10 мм в диаметре [28,59,60], по другим -большинство САК проис-ходят из аневризм менее 10 мм [61][62][63] …”