Unsafe abortion in 2008: global and regional levels and trends

Shah, Iqbal; Åhman, Elisabeth

doi:10.1016/s0968-8080(10)36537-2

Cited by 120 publications

(93 citation statements)

References 20 publications

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“…Several social, health and economic issues should be considered. For example, it was reported that in 2008 the number of unplanned worldwide pregnancies was as high as 20%, and the number of maternal deaths due to unsafe abortions was about 50,000 [191,192]. Unfortunately this is a worldwide problem and, even in the USA, the statistics show a high rate of unintended pregnancies that end in abortion [191].…”

Section: Future Perspectivesmentioning

confidence: 99%

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Alves¹,

Dias²,

Silva³

et al. 2015

CMP

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Abstract:The development of a "male pill" to control fertility is still a major challenge. Although women have several options to play an active role in the couple family planning, men are very limited in terms of contraceptive methods. Several approaches have been proposed to develop a male contraceptive and can be divided in two major groups: hormonal and non-hormonal methods. Within the testis, the somatic Sertoli cell (SC) is known as the "nurse cell" since it provides the physical and nutritional support for the developing germ cells. Moreover, adjacent SCs form the Sertoli/blood testis barrier (BTB), which divides the seminiferous epithelium into the basal and the apical compartments, controlling the passage of substances to the site where germ cells develop. Among the several functions of SC, its metabolism and the production of lactate, acetate and other metabolic factors are essential for the normal occurrence of spermatogenesis. In the last years, several works have highlighted that the metabolic cooperation established between SCs and developing germ cells is compromised in several diseases associated with male subfertility/infertility. Notably, several metabolismassociated proteins are specifically expressed in the testis. Thus, there are several evidences illustrating that the control of male fertility can be achieved by targeting testicular cells metabolism. Herein, we discuss the metabolic cooperation in testis as a potential pharmacological target to counteract subfertility/infertility promoted by several diseases, particularly metabolic diseases. We also discuss how it can contribute to the development of a male contraceptive.

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Section: Future Perspectivesmentioning

confidence: 99%

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Alves¹,

Dias²,

Silva³

et al. 2015

CMP

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“…Developing countries accounted for 86% of all induced abortions. [1,2] The United Nations defines the policy on fertility level in Russia in total, and particularly in Yakutia, as "no intervention" and qualifies the grounds on which abortion is permitted as "least restrictive" (to save a woman's life, in case of rape or incest, and because of fetal impairment). [3] In the Republic of Sakha (Yakutia) (the RS(Y)), women have the fundamental right to abortion as determined by the law.…”

Section: Introductionmentioning

confidence: 99%

Abortion in the Republic of Sakha (Yakutia): Incidence and Trends

Дуглас¹,

Rad²,

Chasnyk³

et al. 2016

Int J Biomed

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Background: The abortion incidence is influenced by many medical and socioeconomic factors. In some way, it indicates the wellbeing of the population, and the abortion statistics can show the ways to improve medical services and to raise the living standards of people. The objective of the study was to estimate the abortion incidence and to describe its current trends in the Republic of Sakha (Yakutia) (the RS(Y)). Materials and Methods:The study was designed as a population-based descriptive study, based on the results of a longitudinal analysis of national and regional reports of the Yakut healthcare services and an analysis of medical records describing 34,220 abortions among women living in all regions of Yakutia, which occurred between 2010 and 2014 and in the first 9 months of 2015.Results: The absolute number of abortions performed each year, the rate of abortions per 1,000 women of fertile age, and the rate of abortions per 100 deliveries declined (P<0.01) by about 37%, 32% and 37%, respectively, between 2006 and 2014. The rate of abortions per 1000 women of fertile age in the first 9 months of 2015 decreased by 1.3%, compared to the same period of 2014 (P=0.05). Though the number of abortions in primigravida women decreases every year, the percentage of them is still rather high, especially at the age of 20 to 24 and 15 to 19, accounting for approximately 2.4% of all abortions. The relative number of miscarriages before 12 weeks of pregnancy increased. Changes in the relative number of abortions performed between 12 to 21 weeks of pregnancy characterized by a decrease in the percentage of miscarriages from 2012 to 2015 and a dramatic increase in the percentage of therapeutic abortions. Conclusion:The revealed trends of the absolute number of abortions and the rates of occurrence in the RS(Y) can be considered in total as favorable, but compared to the data obtained in Russia in total, the dynamics of these trends cannot be regarded as satisfactory. Simplicity of medication abortions can lead to an increase in the absolute number of abortions, especially in adolescents and young women. Analysis of spatial and temporal distribution of the incidence of abortions did not reveal any association with the ethnicity of women.(Int J Biomed. 2016;6(3):218-221.).

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“…1 Some of the reasons in developing countries include the lack of sufficient knowledge on sexual education and reproduction, irregular supply of contraceptive methods, contraceptive failure or fear to use contraceptive methods. 2,3 Only 14% of Cameroonian women of reproductive age were using modern contraceptive methods in 2011.…”

Section: Introductionmentioning

confidence: 99%