Unsaturated fatty acid-tuned assembly of photosensitizers for enhanced photodynamic therapy via lipid peroxidation

A nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment

“…Significant increases in particle size and shifted absorbance bands indicated the disassembly of nanoparticles upon treatment and thus confirmed the presence of π–π stacking, hydrogen bonding, and hydrophobic interactions in the nano-assemblies. 43–45…”

“…Significant increases in particle size and shifted absorbance bands indicated the disassembly of nanoparticles upon treatment and thus confirmed the presence of π-π stacking, hydrogen bonding, and hydrophobic interactions in the nano-assemblies. [43][44][45] The ROS-responsive cleavage of the vinyldithioether linkage was subsequently explored. Ce6-GVS NPs were illuminated at 660 nm (20 mW, 10 cm above the sample), and the corresponding time-dependent degradation behavior was monitored by HPLC, where a rapid release of Smac N7 and Gem was detected after 4 min of illumination.…”

Biomimetically constructing a hypoxia-activated programmable phototheranostics at the molecular level

“…Since 1 O 2 is generally considered the critical ROS in PDT to oxidize biomolecules such as proteins, nucleic acids, or lipids, we chose cholesterol and oleic acid as the examples to test the activity of Ce6-1@NP in the presence of H 2 O 2 under an N 2 atmosphere. [60][61][62] As shown in Fig. 1f and S5, † yields of 16% and 34% of 5a-hydroperoxycholesterol and peroxyl oleic acid were obtained, respectively, ca.…”

Molecularly Self-Engineered Nanoamplifier for Boosting Photodynamic Therapy via Cascade Oxygen Elevation and Lipid ROS Accumulation

“…In comparison with traditional therapies, PDT has a distinct advantage of precise localization with fewer side effects. , However, the effectiveness of PDT is still limited by some thorny issues, particularly the tumor hypoxia. , Since oxygen is one of the essential elements for PDT, improvement of the hypoxic tumor microenvironment is of great significance for efficient cancer eradication. − Besides, the extremely short half-life and limited action range of 1 O 2 represents another inherent drawback of PDT. ,, It is well-known that the half-life of 1 O 2 is less than 40 ns. Moreover, the 1 O 2 works within a range of only 20 nm, which is far smaller than the size of tumor cells …”

“…Moreover, AA could be rapidly oxidized by the generated 1 O 2 into cytotoxic lipid reactive oxygen species (ROS). In comparison with 1 O 2 , a lipid ROS usually has a longer half-life, which could be beneficial for an antitumor effect through deep diffusion to various parts of tumor cells . As a result, AA@PPa/Hemin NPs demonstrated potent antitumor activity in 4T1 breast-tumor-bearing BALB/c mice.…”