Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis

Zi, He; Guo, Yijun; Chen, Jinzhu; Luo, Huiling; Liu, Xinxin; Zhang, Xiuming; Sun, Yanan; Ge, Dongtao; Ye, She-Fang; Shi, Wei

doi:10.1039/d2tb01854c

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Additionally, the Fe 2+ from Ferrocene can transform H 2 O 2 into hydroxyl radicals (•OH), subsequently inducing ferroptosis. To improve the utilization of iron sources and enhance the induction of Lipid peroxidation in cells, 125 FeOCl nanosheets functionalized with unsaturated phospholipids and polyacrylic acid (FeOCl@PAA-Lip) were prepared by He et al 126 These nanosheets enter tumor cells through endocytosis, reacting with H 2 O 2 in tumor cells to generate •OH via the Fenton reaction. The •OH attacks the unsaturated phospholipids on the FeOCl@PAA-Lip, converting them into phospholipid free radicals (L •) and lipid peroxidation free radicals (LOO •), effectively avoiding their annihilation.…”

Section: The Mechanism Of Tumor Cell Ferroptosis Mediated By Nanopart...mentioning

confidence: 99%

“… Satisfactory tumor suppression effects [ 124 ] FeOCl@PAA-Lip - These nanosheets enter tumor cells through endocytosis, reacting with H 2 O 2 in tumor cells to generate •OH via the Fenton reaction. It can more effectively inhibit tumor growth, and the tumor suppression rate can reach 73.3% [ 125 , 126 ] Fe 3 O 4 -PEI@HA-RSL3 RSL3 Hyaluronic acid and magnetic field Inhibiting the expression of Lactoferrin, FACL4, GPX4, and Ferrin protein in Huh 7 cancer cells [ 128 ] MIL-101(Fe)@sor NPs Sorafenib Inhibition of GPX-4 activity induces ferroptosis. Notably promote lipid ROS accumulation and accelerate ferroptosis occurrence in HCC.…”

Section: The Mechanism Of Tumor Cell Ferroptosis Mediated By Nanopart...mentioning

confidence: 99%

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Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

Xiang,

Zhou,

Yang

et al. 2024

IJN

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Currently, cancer remains one of the most significant threats to human health. Treatment of most cancers remains challenging, despite the implementation of diverse therapies in clinical practice. In recent years, research on the mechanism of ferroptosis has presented novel perspectives for cancer treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane unsaturated fatty acids catalyzed by iron ions. The rapid development of bio-nanotechnology has generated considerable interest in exploiting iron-induced cell death as a new therapeutic target against cancer. This article provides a comprehensive overview of recent advancements at the intersection of iron-induced cell death and bionanotechnology. In this respect, the mechanism of iron-induced cell death and its relation to cancer are summarized. Furthermore, the feasibility of a nano-drug delivery system based on iron-induced cell death for cancer treatment is introduced and analyzed. Secondly, strategies for inducing iron-induced cell death using nanodrug delivery technology are discussed, including promoting Fenton reactions, inhibiting glutathione peroxidase 4, reducing low glutathione levels, and inhibiting system Xc − . Additionally, the article explores the potential of combined treatment strategies involving iron-induced cell death and bionanotechnology. Finally, the application prospects and challenges of iron-induced nanoagents for cancer treatment are discussed.

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Section: The Mechanism Of Tumor Cell Ferroptosis Mediated By Nanopart...mentioning

confidence: 99%

Section: The Mechanism Of Tumor Cell Ferroptosis Mediated By Nanopart...mentioning

confidence: 99%

Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

Xiang,

Zhou,

Yang

et al. 2024

IJN

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“…He et al published a volatile microemulsion method for converting non-water soluble photoabsorbers into water-soluble nanoparticles, which were shown to be effective in multimaterial hydrogel 4D printing of NIPAm and acrylamide bilayers. [122] It is also very important to ensure that the photopolymerized hydrogels have very strong adhesion to both the build plate and each other. We recommend starting with a longer exposure time for the first layer to guarantee a good bind to the build plate.…”

Section: Vat-switching During Multimaterials Hydrogel 3d Printingmentioning

confidence: 99%

Multimaterial Hydrogel 3D Printing

Imrie,

Jin

2023

Macro Materials & Eng

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In recent years, hydrogels have emerged as quintessential 3D printing materials. Coupled with their inherent printability, the unique mechanical properties, network structure, and biocompatibility of hydrogels make them ideal for a wide range of 3D printing applications. Also in recent years, the rise of multimaterial 3D printing, an additive manufacturing technology which involves at least two different materials in the fabrication process, has been witnessed. Advanced multimaterial 3D printing protocols have brought the field closer than ever before to a new industrial revolution. In this review, the use of hydrogels in multimaterial 3D printing is investigated. The review is sectioned by discussing three major multimaterial 3D printing methods: direct‐ink‐writing, vat‐switching, and coaxial extrusion. Subsections detail three common domains of multimaterial hydrogel 3D printing: bioprinting, 4D printing, and particle‐polymer composite printing. In the second part of the review, recent advancements in both multimaterial 3D printing hardware and hydrogel inks which are expected to steer the field in exciting new directions are explored. Finally, a case is made for coaxial extrusion and light‐responsive printers being the best choice for multimaterial hydrogel 3D printing in the long run, due to their gradient and greyscale printing capabilities.

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“…Compared with the bulk, the 2D materials can be further manipulated by various methods, such as strain engineering, 24,25 composition modulation, 26,27 surface functionalization, 28 stacking 29 and defect engineering, 30 to achieve the ideal physical properties for targeted applications. Although numerous studies have been conducted on 2D metal oxyhalides in recent years, [13][14][15][16]22,23 research on 2D sulfide halides still remains limited.…”

Section: Introductionmentioning

confidence: 99%

Mechanical, magnetic and electronic properties of 2D MSX (M = Ti, V, Co and Ni, X = Br and I)

Li¹,

Li²,

Bai³

et al. 2023

Phys. Chem. Chem. Phys.

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Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis

Abstract: Iron-dependent accumulation of reactive oxygen species (ROS) and lipid peroxidation plays key roles in ferroptosis, which has been an attractive strategy to kill tumor cells. However, the rapid annihilation of...

Cited by 7 publications

References 41 publications

Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

Multimaterial Hydrogel 3D Printing

Mechanical, magnetic and electronic properties of 2D MSX (M = Ti, V, Co and Ni, X = Br and I)

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