The Republic of Moldova is today one of the countries which is considerably affected by migration. Almost 25% of the economically active population of the country is involved in temporary labor migration. According to the data offered by the Ministry of Health, Labor and Social Protection of the Republic of Moldova, at the beginning of 2020, the total number of children affected by parental labor migration was 29 186. In order to define the quality of life (QL) of migrants’children, there were researched different aspects of their lives, such as physical functioning (FF), emotional functioning (EF), social functioning (SF) and school functioning (SF). The given research involved 150 children from Moldova. They were of different age groups (5-7, 8-12, 13-18), from whom 75 children were of the labor migrants and their parents/tutors who remain in the country and 75 children of the labor migrants without labor migration experience. As the instrument for given research there was used the Pediatric Quality of Life Inventory (PedsQL™4.0) questionnaire. In the course of the research there was emphasized the quality of life of children of the highest level with the score from 100 to 91, the middle level from 90 to 81, the low level from 80 to 71 and the lowest level less than 70 points. According to the results of the investigation it was established that the migrants’ children of various age groups, from all the examined aspects had a very low level of QL (less than 70 points). The presented results perform a very convincing fact that labor migrants’ children in comparison to their peers from the families without labor migration experience had a considerably low index on all the scales and on integral characteristics of quality of life.