Unstable alleles of the singed locus in Drosophila melanogaster with reference to a transposon marked with a visible mutation

Yurchenko, N. N.; Захаров, И. К.; Golubovsky, M. D.

doi:10.1007/bf00383528

Cited by 5 publications

(9 citation statements)

References 16 publications

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“…Such diversity is not typical of bypermutable alleles resulting from a double P element insertion. Super-instability in our system is most similar to that described by Golubovsky et al in natural populations of D. melanogaster (Golubovsky, Ivanov & Green, 1977;Yurchenko, Zakharov & Golubovsky, 1984).…”

Section: Discussionsupporting

confidence: 88%

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Super-unstable mutations associated with P-M hybrid dysgenesis in Drosophila melanogaster

Georgiev

Yelagin

1992

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Super-unstable mutations occasionally appear either in natural populations of Drosophila melanogaster or in P-M hybrid dysgenesis. We found that they may be reproducibly obtained with a high frequency from crosses between males from the pi 2 strain and females from the waG* strain or its derivatives. Super-unstable mutations in the ocelliless, singed, white, yellow and other loci have been obtained. Each super-unstable mutation gives rise to a large family of new super-unstable mutations with a wide range of phenotypic expression. Mutations with the same phenotype often differ in the specificity of their potential for further mutation. As a rule, a super-unstable mutation is associated with a specific reversible mutation and paired alleles are formed in this way. Other mutations are usually irreversible, but new mutations of these may also form paired alleles. Active transposase encoded by transposable P elements is necessary to maintain super-instability. Finally, some preliminary molecular data are discussed which suggest that this type of super-instability is a result of interaction between P elements and a novel mobile element, designated as X.

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Section: Discussionsupporting

confidence: 88%

“…melanogaster (Golubovsky, Ivanov & Green, 1977;Yurchenko, Zakharov & Golubovsky, 1984). In the course of maintaining super-unstable oc mutations, the property of super-instability has apparently spread to several other loci, in particular the yellow and scute ones.…”

Section: Introductionmentioning

confidence: 99%

Super-unstable mutations associated with P-M hybrid dysgenesis in Drosophila melanogaster

Georgiev

Yelagin

1992

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“…Some other mechanisms, such as changes due to genetic instability, cannot be excluded (Demerec, 1927;Yurchenko et al, 1984).…”

Section: Resultsmentioning

confidence: 99%

Change of the crossing-over frequency inDrosophila during selection for resistance to temperature fluctuations

Жученко¹,

Korol²,

Kovtyukh³

1985

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Significant differences among cage populations of Drosophila in the dynamics of linkage disequilibrium for marker loci b. cn and vg of chromosome 2 have been found at optimum and extreme temperatures. Fifteen generations of selection under extreme conditions considerably increased recombination frequency in the cn-vg region and over the whole of the b-vg interval. From the data obtained it is inferred that recombination--promoting alleles with intermediate expression in the heterozygous state are responsible for these changes.

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“…Derivatives with altered bristle phenotypes were grouped by descent into three pleiads as described by Yurchenko et al (1984). They were characterised by the type and frequency with which they, in turn, produced derivatives with altered bristle phenotypes.…”

Section: Drosophila Strainsmentioning

confidence: 99%

“…A series of unstable sn mutants of Drosophila melanogaster have been described which are descended from ies caught in Russia between 1973 and 1979 (Ivanov and Golubovsky 1977;Yurchenko et al 1984). One of these, singed-49 (sn 49 ), is the subject of this investigation.…”

Section: Introductionmentioning

confidence: 99%

Rearrangements at a hobo element inserted into the first intron of the singed gene in the unstable sn 49 system of Drosophila melanogaster

et al. 1998

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The cytological structure of the X chromosome and the DNA organisation of the singed locus were examined in five singed bristle mutants of Drosophila melanogaster. These mutants are all derived from the unstable mutant singed-49, isolated from a wild population in the Russian Far East in 1975. Rearrangements were found at a site within the first intron of the singed gene, where a hobo element is inserted in these mutants. One rearrangement, which is associated with a strong bristle phenotype, has an inversion between 2D and the location of singed at 7D, which separates the singed promoter from the singed coding region. Two phenotypically wild-type derivatives have smaller rearrangements within the first intron which do not appear to interfere with singed expression. Two derivatives with bristle phenotypes have more complex rearrangements, and one of them shows a dominant or antimorphic phenotype. DNA blotting and in situ hybridisation experiments show that, in addition to these rearrangements at a hobo element inserted at singed, other hobo elements in these strains have been mobilised. This system is therefore similar to others in which functional hobo elements continue to transpose, resulting in elevated rates of mutation and chromosome rearrangement.

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Unstable alleles of the singed locus in Drosophila melanogaster with reference to a transposon marked with a visible mutation

Cited by 5 publications

References 16 publications

Super-unstable mutations associated with P-M hybrid dysgenesis in Drosophila melanogaster

Super-unstable mutations associated with P-M hybrid dysgenesis in Drosophila melanogaster

Change of the crossing-over frequency inDrosophila during selection for resistance to temperature fluctuations

Rearrangements at a hobo element inserted into the first intron of the singed gene in the unstable sn 49 system of Drosophila melanogaster

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