Purpose. To study hydraulic losses in pumping units during pumping and transportation of liquids, to develop the design and technology solutions to improve the energy efficiency of centrifugal pumps in the mining and oil-producing industries. Methodology. In the theoretical and experimental analysis of hydraulic losses during the transportation of liquids, the hydraulics and experimental analysis methods were used. Findings. As a result of the research carried out, a new design scheme of a multistage centrifugal pump has been developed, providing a coaxial arrangement of impellers, which allows reducing hydraulic losses in pump elements and increasing the energy efficiency of pumping units. Originality. Based on the analysis of existing designs of multistage blowers of axial and centrifugal types, the distribution of hydraulic losses in the elements of a centrifugal blower with coaxial impellers is considered. Experimental dependences on the establishment of pressure flow and power characteristics are presented. Based on the accounting of hydraulic losses, the energy efficiency of the design of the pumping unit with the coaxial arrangement of the impellers was assessed. Practical value. The new design of a centrifugal pump with coaxial impellers reduces hydraulic losses by more than 23% compared to traditional designs of centrifugal pumps. The results of the work can be used by design, research, and industrial organizations engaged in the design and operation of pumping equipment.