Unstructured hexahedral mesh generation of complex vascular trees using a multi-block grid-based approach

Bols, Joris; Taelman, Liesbeth; Santis, Gianluca De; Degroote, Joris; Verhegghe, Benedict; Segers, Patrick; Vierendeels, Jan

doi:10.1080/10255842.2015.1058925

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…Finally, the segmented geometry was shrunk to the diastolic radius as measured with M-mode, resulting in a geometrical shrinking factor of 0.84. From the resulting STL-surface, a volume mesh of both the fluid (lumen) and the solid (arterial wall) domain was constructed using the in-house developed XTM meshing method (Bols et al, 2016). A mesh convergence study resulted in convergence for 300k fluid domain cells and 65k solid domain cells (De Wilde et al, 2015a).…”

Section: Post-processing Of the Measurementsmentioning

confidence: 99%

The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

Wilde

Trachet

Meyer

et al. 2016

Journal of Biomechanics

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Segers, the Influence of anesthesia and fluid-structure interaction on simulated shear stress patterns in the carotid bifurcation of mice, Journal of Biomechanics, http://dx.doi.org/10. 1016/j.jbiomech.2016.06.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Post-processing Of the Measurementsmentioning

confidence: 99%

The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

Wilde

Trachet

Meyer

et al. 2016

Journal of Biomechanics

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“…After segmentation, the outer surface of the lumen geometry was represented by a triangulated surface mesh and exported into the stereolithographic (STL) file format. This geometry file was subsequently passed on to the extended Treemesh method, a parametric interface that has been implemented in pyFormex to generate hexahedral meshes [24]. Finally, a computational grid for the arterial wall was generated using quadratic hexahedral elements with a hybrid formulation.…”

Section: Geometrical Model Of the Abdominal Aortamentioning

confidence: 99%

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

et al. 2015

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Recent research has revealed that angiotensin II-induced abdominal aortic aneurysm in mice can be related to medial ruptures occurring in the vicinity of abdominal side branches.Nevertheless a thorough understanding of the biomechanics near abdominal side branches in mice is lacking. In the current work we present a mouse-specific fluid-structure interaction (FSI) model of the abdominal aorta in ApoE -/-mice that incorporates in vivo stresses. The aortic geometry was based on contrast-enhanced in vivo micro-CT images, while aortic flow boundary conditions and material model parameters were based on in vivo high-frequency ultrasound. Flow waveforms predicted by FSI simulations corresponded better to in vivo measurements than those from CFD simulations. Peak-systolic principal stresses at the inner and outer aortic wall were locally increased caudal to the celiac and left lateral to the celiac and mesenteric arteries. Interestingly, these were also the locations at which a tear in the tunica media had been observed in previous work on angiotensin II-infused mice. Our preliminary results therefore suggest that local biomechanics play an important role in the pathophysiology of branch-related ruptures in angiotensin-II infused mice. More elaborate follow-up research is needed to demonstrate the role of biomechanics and mechanobiology in a longitudinal setting.

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“…It turns out that in near‐wall regions and in boundary layers, where large gradients in the velocity field appear, stretched hexahedra typically perform better than stretched tetrahedrons. See [GJTP17] and [BTDS*16] for recent methods to create mixed meshes with tetrahedral and hexahedral elements. Often, also prismatic cells are used (Figure ); for a recent algorithm creating mixed meshes of tetrahedral, prismatic and hexahedral cells see [BLC16].…”

Section: Flow Data Generation Pipelinementioning

confidence: 99%

Generation and Visual Exploration of Medical Flow Data: Survey, Research Trends and Future Challenges

Oeltze-Jafra

Meuschke

Neugebauer

et al. 2018

Computer Graphics Forum

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Simulations and measurements of blood and airflow inside the human circulatory and respiratory system play an increasingly important role in personalized medicine for prevention, diagnosis and treatment of diseases. This survey focuses on three main application areas. (1) Computational fluid dynamics (CFD) simulations of blood flow in cerebral aneurysms assist in predicting the outcome of this pathologic process and of therapeutic interventions. (2) CFD simulations of nasal airflow allow for investigating the effects of obstructions and deformities and provide therapy decision support. (3) 4D phase‐contrast (4D PC) magnetic resonance imaging of aortic haemodynamics supports the diagnosis of various vascular and valve pathologies as well as their treatment. An investigation of the complex and often dynamic simulation and measurement data requires the coupling of sophisticated visualization, interaction and data analysis techniques. In this paper, we survey the large body of work that has been conducted within this realm. We extend previous surveys by incorporating nasal airflow, addressing the joint investigation of blood flow and vessel wall properties and providing a more fine‐granular taxonomy of the existing techniques. From the survey, we extract major research trends and identify open problems and future challenges. The survey is intended for researchers interested in medical flow but also more general, in the combined visualization of physiology and anatomy, the extraction of features from flow field data and feature‐based visualization, the visual comparison of different simulation results and the interactive visual analysis of the flow field and derived characteristics.

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Unstructured hexahedral mesh generation of complex vascular trees using a multi-block grid-based approach

Cited by 12 publications

References 26 publications

The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Generation and Visual Exploration of Medical Flow Data: Survey, Research Trends and Future Challenges

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