Unterdrückung der Fortpflanzungsaktivität durch aktive Immunisierung gegen GnRH beim adulten weiblichen Schaf

Janett, F.; Lanker, U.; Jörg, H.; Meijerink, Edwin; Thun, R.

doi:10.1024/0036-7281.151.2.53

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…The suppression of reproductive function using an anti-GnRF vaccine has been demonstrated in numerous studies in cattle [3][4][5][6][7][8][9][10][11][12][13], sheep [10,[14][15][16][17][18][19][20][21], pig [22][23][24][25][26][27][28], horse [29][30][31][32][33][34] and in wild animals [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Janett

Gerig

Tschuor³

et al. 2012

Theriogenology

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The aim of this study was to evaluate the effects of vaccination against gonadotropin-releasing factor (GnRF) on testicular development, testosterone secretion, and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 mo. Twenty-three animals were vaccinated twice 4 wk apart with 1 mL of Bopriva (Pfizer, Animal Health, Parkville, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 wk from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody titers to GnRF began to rise 2 wk after the first vaccination and reached peak values 2 wk after the second injection. Significant group differences in anti-GnRF titer were present for 22 wk following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls with Bopriva compared with control animals. In vaccinated bulls testicular development was impaired after the second injection and scrotal circumference was significantly smaller between weeks 8 to 24 after first vaccination. Physical activity of vaccinated bulls was reduced after the booster injection with significant group differences for a continuous period of 106 days. In conclusion, vaccination against GnRF with Bopriva in pubertal bulls decreased testosterone levels in peripheral blood, testicular development, and physical activity but did not affect weight gain. AbstractThe aim of this study was to evaluate the effects of vaccination against gonadotropinreleasing factor (GnRF) on testicular development, testosterone secretion and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 months. Twenty-three animals were vaccinated twice 4 weeks apart with 1 mL of Bopriva ® (Pfizer Animal Health, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 weeks from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO  DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody 2 titers to GnRF began to rise 2 weeks after the first vaccination and reached peak values 2 weeks after the second injection. Significant group differences in anti-GnRF titer were present for 22 weeks following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls w...

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Section: Introductionmentioning

confidence: 99%

Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Janett

Gerig

Tschuor³

et al. 2012

Theriogenology

Self Cite

View full text Add to dashboard Cite

show abstract

“…After immunization against GnRF, antibodies neutralize the endogenous GnRF resulting in the suppression of secretion of the gonadotropins LH and FSH in the anterior pituitary. The effectiveness of vaccination against GnRF could be demonstrated in numerous studies in cattle (Aissat et al, 2002;Cook et al, 2000;D'Occhio et al, 2001;Finnerty et al, 1998;Geary et al, 2006;Hoskinson et al, 1990;Jago et al, 1997;Jeffcoate et al, 1982;Neeson and Colson, 2004;Stevens et al, 2005;Theubet et al, 2010), sheep (Brown et al, 1994(Brown et al, , 1995Ferro et al, 2004;Janett et al, 2003Janett et al, , 2009aJeffcoate et al, 1982;Ülker et al, 2005), pig (Bonneau et al, 1994;Clarke et al, 2008;Claus et al, 2007;Dunshea et al, 2001;Fuchs et al, 2009;Jaros et al, 2005;Zamaratskaia et al, 2008), horse (Dalin et al, 2002;Elhay et al, 2007;Imboden et al, 2006;Janett et al, 2009b;Schanbacher and Pratt, 1985;Turkstra et al, 2005) and in wild animals (Curtis et al, 2002;Miller et al, 2000Miller et al, , 2004.…”

Section: Introductionmentioning

confidence: 99%