Untersuchungen der Thrombocytenaggregation und der Gerinnselretraktion bei reifen und unreifen Neugeborenen

Abstract

The aggregation of blood platelets and the retraction of the clot were measured during the first 21 days of life in the blood of premature and newborn infants. The results were compared with those of children at the age of 6 to 14 years. At first the aggregation of blood platelets is diminished in premature and newborn infants in comparison with the results of school children. But in the period of 3 weeks of investigation a rise in the platelet aggregation is seen.The clot retraction of newborn babies in the first days of life is the same as in healthy school children. After this time the weight of the clot rises in premature and mature newborn infants. The reason for diminished clot retraction is thought to be a high number of young platelets among the whole population of blood platelets.

Comparable Inhibition of Aggregation of PRP of Neonates and Adults by Aspirin

“…With this in mind, we studied the relative sensitivity of PRP of neonates and adults to 4 aggregating agents, and the inhibition of ASA on neonatal and adult PRP aggregation. Our data confirmed observations of previous investigators [5,[8][9][10][11]16] that PRP of neonates is less aggregable by physiologic aggre gating agents than that of adults. However, adult level of aggregation of neonatal PRP could be achieved with greater concentrations of ADP and collagen.…”

“…It is interesting to note that several aspects of the behavior of neonatal PRP are reminiscent of that of adult PRP in certain hemorrhagic diathesis [4,7]. However, the defects of neonatal platelets are present only transiently; markedly improved platelet aggregation is observed within 3 weeks of birth [10].…”

“…The reason for the decreased sensitivity of neonatal PRP to aggre gating agents is not clear. Most investigators [8,10,11] consider it to repre sent an abnormality or developmental change of neonatal platelets. If this is the case, the precise loci the defects reside remain to be identified.…”

“…The aggregability of platelets of neonates has been a subject of several reports [5,[8][9][10][11]. Most investigators have observed diminished responses of neonatal platelets to physiologic aggregating agents such as adenosine di-phosphate (ADP), epinephrine, collagen and thrombin.…”

Die spontane, standardisierte Thrombozytenadhäsion und -aggregation in der Zählkammer

“…Hyperkoagulämie [1, 17,26] sind in den ersten Lebenstagen die Einzelgerinnungsfak toren herabgesetzt [17], In letzter Zeit kamen auch erste ausführlichere 1 Herrn Prof. Dr. J. Ströder Berichte über vorübergehende quantitative und qualitative Thrombozy tenveränderungen bei Neugeborenen in den ersten Lebenstagen [15,20,21].…”