Untersuchungen über die Lockerungsursache bei zementierten Hüftgelenkendoprothesen

Bos, Inge; Lindner, B; Seydel, Ulrich; Johannisson, R.; Dörre, E; Henssge, J; Löhrs, U.

doi:10.1055/s-2008-1039865

Cited by 18 publications

(3 citation statements)

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“…Die Quantifizierung von phagozytiertem Abriebmaterial ist schwierig (Bos et al 1990) und erfolgte meist indirekt durch Gewebeuntersuchungen (Agins et al 1988. Es wurden jeweils die in Kapitel 2.…”

Section: Oberflächenuntersuchungenunclassified

“…Deren sehr große Gesamtoberfläche unterliegt chemischen und physikalischen Reaktionen (Lee JM et al 1992 und kann eine als Partikelkrankheit bezeichnete aseptische lokal-entzündliche Gewebereaktion auslösen (zellulärer Mechanismus siehe Anhang B). Die Anzahl der aktivierten Makrophagen korreliert positiv mit der Partikellast (Bos et al 1990). Phagozytierte Metallpartikel können während der lysosomalen Lagerung durch intrazelluläre Korrosion toxische Mengen an Metallionen freisetzen und ihrerseits zur Degeneration und zum Zelltod der Makrophagen führen (Brien et al 1992und Salvati et al 1993.…”

Section: Rubmarks In Anderen Studienunclassified

“…über den effektiven Gelenkraum (Schmalzried et al 1992) zur Gelenkkapsel und zum Gleitlager und ggf. die systemische Verteilung via Lymphgefäße (Bos et al 1990, Baslé et al 1996, Urban et al 2004 werden im Anhang B ausführlich beschrieben. Ebenso wurden dort weitere biologische Folgen des Metallabriebs wie allergische Überempfindlichkeitsreaktionen (Kaddick et al 2009, Thomas et al 2009), der Einfluss löslicher Metallionen auf die Zytokin-Genexpression (Sundfeldt et al 2006), die irreversible biochemische Schädigung von Makromolekülen durch oxidativen Stress (Huo et al 2009), das eher unwahrscheinliche (Katzer et al 2003) carcinogene Risiko von Metallabrieb (Brien et al 1992), sowie Einflüsse auf Hämatopoese und kognitive Leistungsfähigkeit (Jacobs et al 1998) Prothesensysteme sowie verwendete Werkstoffe vergleichen zu können (Bos et al 1990).…”

Section: Signifikanteunclassified

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Lokalisation und Volumenberechnung von femoralem Schaftabrieb an explantierten, zementierten Hüftendoprothesenschäften vom Typ CF-30 und dessen Relevanz als Faktor der aseptischen Lockerung

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Section: Oberflächenuntersuchungenunclassified

Section: Rubmarks In Anderen Studienunclassified

Section: Signifikanteunclassified

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Lokalisation und Volumenberechnung von femoralem Schaftabrieb an explantierten, zementierten Hüftendoprothesenschäften vom Typ CF-30 und dessen Relevanz als Faktor der aseptischen Lockerung

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Organic and inorganic analysis with laser microprobe mass spectrometry. Part II: Applications

Vaeck

Struyf

Roy

et al. 1994

Mass Spectrometry Reviews

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Irradiation of an inorganic solid under high-power density conditions leads to spectra that primarily contain signals from elemental ions. This information is comparable to that from other microprobes in the respect that identification of inorganic compounds has to be done by means of element ratios. However, a lower energy regime results in spectra that permit speciation of the analyte in a relatively straightforward way.The procedures for the interpretation of inorganic LMMS data spectra can be based on a substantial amount of reference data, most of which were obtained by TOF instruments. Cluster ion distributions have been recorded for several pure elemental materials, metals, and alloys (140,(168)(169). Studies have been performed on the most common binary salts, such as halides and sulfides (90,(170)(171)(172)(173). The mass spectra of the major oxysalts are available, including nitrates and nitrites, sulphates, sulphites and thiosulphates, phosphates, silicates, and carbonates (90,(172)(173)(174)(175)(176)(177)(178). In addition, salts such as NaBF4 and KPF, were studied (171). Reference spectra have been recorded from an impresive series of oxides (83, 117, 170, 172, 174,(177)(178)(179)(180)(181)(182)(183)(184)(185). The intensity distribution of the cluster-ion spectra from oxides has been found to be similar to the ones in static SIMS, but the empirical model of Plog (186), relating the intensity distribution of cluster ions to the fragment valence, was not entirely applicable to laser-generated ions from oxides (183).In practice, ion signals in threshold spectra can be readily correlated to the original composition of the analyte using a few simple guidelines. Figure 6 gives a few representative examples (83). The identification of binary salts can be based on the low m / z signals in the positive and negative mode and on the detection of a cationized and anionized molecule. Oxides are recognized by the fact that the metal oxide constitutes the building block of clusters in both positive and negative mass spectra, as opposed to oxysalts. Oxysalts produce positive metaloxide-type clusters in the positive mode, but in the negative spectra signals from the anion appear. As shown in Fig. 6, even sodium sulphate and sodium sulphite can be readily distinguished by the rule that the anion with the highest oxygen number refers to the originally present anion. The presence of the cationized molecules in the positive mass spectrum of oxysalts seems to be related to the desorption characteristics of the analyte. Salts requiring more energy to yield a significant ion current do not show this signal. The ultimate test for the speciation capabilities remains the characterization of multicomponent systems. It has been shown that LMMS permits the identification of the individual components from mixtures containing chloride, sulphate, and nitrate salts (187). It is quite clear that the determination of the composition using relative element ratios would be rather difficult in such cases.Note, however, that the local en...

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Laser Microprobe Mass Spectrometry: Principle and Applications in Biology and Medicine

Vaeck

Poels

Nollin

et al. 1997

Cell Biology International

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Laser microprobe mass spectrometry (LMMS) is an interesting technique for micro- and surface analysis. It employs local ionization by a focused laser under high power density conditions and subsequent mass analysis of the generated ions. This paper surveys the main LMMS instruments and their operational principles. Sample preparation is discussed in the context of biological materials. The problem of quantification is addressed. Selected examples show the way that precise information on the molecular composition can be deduced from the detected signals. Both inorganic and organic substances can be identified, even without reference spectra, from in-situ analysis with a lateral resolution in the order of 1 to 5 micrograms.

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Untersuchungen über die Lockerungsursache bei zementierten Hüftgelenkendoprothesen

Cited by 18 publications

References 1 publication

Lokalisation und Volumenberechnung von femoralem Schaftabrieb an explantierten, zementierten Hüftendoprothesenschäften vom Typ CF-30 und dessen Relevanz als Faktor der aseptischen Lockerung

Lokalisation und Volumenberechnung von femoralem Schaftabrieb an explantierten, zementierten Hüftendoprothesenschäften vom Typ CF-30 und dessen Relevanz als Faktor der aseptischen Lockerung

Organic and inorganic analysis with laser microprobe mass spectrometry. Part II: Applications

Laser Microprobe Mass Spectrometry: Principle and Applications in Biology and Medicine

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