Untersuchungen über die Wirkung von Glucagon auf das sympatho-adrenale System des Menschen

Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urine

“…The reports that large doses of glucagon release catecholamines into the circulation (22)(23)(24)(25) and the effects of these hormones on cyclic AMP formation in many tissues (1) prompted consideration of a possible role of the catecholamines in the cyclic AMP response to glucagon. An intravenous infusion of a rather large dose of epinephrine in a normal subject caused modest increases in plasma and urinary levels of cyclic AMP (Fig.…”

“…Finally, large doses of glucagon in man and laboratory animals have been shown to elevate circulating levels of the catecholamines (22)(23)(24)(25), hormones which stimulate adenyl cyclase systems in a wide variety of tissues (1).…”

Glucagon-Induced Growth Hormone Release in Children

“…It has been shown in recent in vivo studies in rats, using in¬ jections into the lateral ventricles of the brain, that 3',5'-AMP itself which only slowly permeates through cell membranes (Sutherland 8c Robison 1966) does not stimulate GH release (Midler et al 1969). Another hormonal action of glu¬ cagon, i. e. the stimulation of adrenal catecholamine secretion (Sarcione et al 1962;Kuschke et al 1966; Lefebvre 8c Luyckx 1968) could be relevant for GH release, providing that the in vivo experiments in monkeys which show plasma GH increases following adrenaline injections (Meyer 8c Knobil 1967; Gagliardino 8c Martin 1968), were transferable to man. In children there appear to be no studies on this effect of adrenaline; adults do not respond (Roth et al 1963 & ;Schalch 1967).…”