Untersuchungen über Größe, Wandstärke und mikroskopischen Aufbau des Herzbeutels unter normalen und pathologischen Bedingungen

Hort, W; Braeun, H

doi:10.1007/bf02119380

Cited by 23 publications

(7 citation statements)

References 25 publications

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“…Finally, the pericardium has considerably capacity for expansion in chronic cardiac dilatation (Hort and Braun, 1962) and shows plastic deformation with repeated distensions (Morgan, 1965). Thus, it is impossible to generalize the results of our acute animal experiments to chronic diseased hearts.…”

Section: Function Of Pericardium For Mechanical Interactionmentioning

confidence: 90%

Mechanical interactions between four heart chambers with and without the pericardium in canine hearts.

Maruyama¹,

Ashikawa²,

Isoyama³

et al. 1982

Circulation Research

102

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By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) the right ventricle and left ventricles, (3) the atrium and one ventricle vs. the other ventricle, and finally (4) the left and right atrium and the right ventricle vs. the left ventricle. For these purposes, we inserted compliant balloons into the four heart chambers without injuring the pericardium, i.e., we incised the base of the atria which was not covered with the pericardium. We obtained the right and/or left ventricular pressure-volume relationships under a constant pressure in three other heart chambers by changing the height of the reservoir connected to each balloon. As a result, both ventricular pressure-volume relationships were hardly affected by an increase in the atrial pressure ranging from 5 to 30 cm H2O with the pericardium removed, although the ventricle became less compliant due to an increase of the same magnitude of the opposite ventricular pressure. On the other hand, the effect of an increase in atrial pressure was distinct with the pericardium intact. Also, all mechanical interactions were enhanced dramatically with the intact pericardium. Thus, the pericardium plays an important role in these mechanical interactions, especially when the filling pressures of all heart chambers increase simultaneously. Clinically, these findings may be important to understanding ventricular functions as related to various heart disease-especially acute heart failure.

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Section: Function Of Pericardium For Mechanical Interactionmentioning

confidence: 90%

Mechanical interactions between four heart chambers with and without the pericardium in canine hearts.

Maruyama¹,

Ashikawa²,

Isoyama³

et al. 1982

Circulation Research

102

View full text Add to dashboard Cite

show abstract

“…Hort and Bräun analyzed 200 human pericardia of almost all age groups using microscopy. 26 Interestingly, collagen fibers of young patients (20–40 years) showed a higher waviness compared to old patients (≥70 years). 26 Furthermore, pericardia of old patients revealed signs of atrophy and degeneration.…”

Section: Discussionmentioning

confidence: 91%

“…26 Interestingly, collagen fibers of young patients (20–40 years) showed a higher waviness compared to old patients (≥70 years). 26 Furthermore, pericardia of old patients revealed signs of atrophy and degeneration. 26 Based on these findings the authors hypothesized a higher tensibility of pericardium in young compared to old patients.…”

Section: Discussionmentioning

confidence: 91%

“…26 Based on these findings the authors hypothesized a higher tensibility of pericardium in young compared to old patients. 26 Similarly, Wallraff estimated tensibility of human collagen fibers based on wave height and number of waves per millimeter using microscopy. 27 Moreover, he also performed modified tensile tests by injecting air into the pericardial sac.…”

Section: Discussionmentioning

confidence: 99%

“…26 Furthermore, pericardia of old patients revealed signs of atrophy and degeneration. 26 Based on these findings the authors hypothesized a higher tensibility of pericardium in young compared to old patients. 26 Similarly, Wallraff estimated tensibility of human collagen fibers based on wave height and number of waves per millimeter using microscopy.…”

Section: Discussionmentioning

confidence: 99%

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Influence of inflammation and cardiac hypertrophy on mechanical properties of human pericardium

Schott

Schröder

Kolthoum

et al. 2022

Proc Inst Mech Eng H

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Different devices for mechanical circulatory support (MCS) have been developed for the treatment of refractory cardiogenic shock. However, all of them are associated with direct blood contact, the need for anticoagulation and bleeding complications. To overcome these limitations the pericardial sac got into the focus as a promising implantation site for MCS. For this purpose, further knowledge about the mechanical properties of human pericardium is required. In this prospective, monocentric, experimental pilot study 56 samples of human pericardium were extracted postmortem from 13 critically ill patients. After preparation of test specimens uniaxial tensile tests were performed. The primary end points were load at fracture per sample width and strain at fracture. Acute inflammation was assessed by blood levels of C-reactive protein, white blood count and procalcitonin measured at several times during hospital stay. Inflammatory load was estimated by area under the inflammatory curves. Correlation and regression analysis were used to assess the relationship of primary end points to inflammation, comorbidities and postmortem time to preparation. Human pericardium showed a load at fracture per sample width of 1.95 [1.38–2.94] N/mm (median [inter quartile range]) and a strain at fracture of 89.29 [73.84–135.23] %. Markers of acute inflammation and cardiac hypertrophy did not correlate to load or strain at fracture. However, strain at fracture increased with higher body mass index and an increasing number of postmortem days. In contrast, higher patient age was associated with a lower strain at fracture. Inflammation and cardiac hypertrophy did not influence mechanical properties of human pericardium.

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Anatomy

Shabetai¹

2003

The Pericardium

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Untersuchungen über Größe, Wandstärke und mikroskopischen Aufbau des Herzbeutels unter normalen und pathologischen Bedingungen

Cited by 23 publications

References 25 publications

Mechanical interactions between four heart chambers with and without the pericardium in canine hearts.

Mechanical interactions between four heart chambers with and without the pericardium in canine hearts.

Influence of inflammation and cardiac hypertrophy on mechanical properties of human pericardium

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