Untersuchungen zum Calcium- und Phosphatstoffwechsel Fr�hgeborener

Hvels, O.; Thilenius, Otto G.; Krafczyk, S.

doi:10.1007/bf00436048

Cited by 11 publications

(1 citation statement)

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“…This variability may expose infants to Ca deficiency and thus prevent optimal bone mineralization even when following current recommendations or using current commercial infant formulas. It was expected that absolute Ca absorption would increase because a linear relation between Ca supply and absorption has been demonstrated (34). To meet the Ca demand for intrauterine growth and Ca accretion rates even in patients with low Ca absorption, the Ca dose in the treated group was 2‐ to 2.5‐fold higher than in the most recent European recommendations (35), thus accepting an oversupply in patients with slower growth or better absorption.…”

Section: Discussionmentioning

confidence: 99%

Results of Extremely‐low‐birth‐weight Infants Randomized to Receive Extra Enteral Calcium Supply

Carroll

Fabres

Nagy³

et al. 2011

J. pediatr. gastroenterol. nutr.

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Background Bone mineral deficiency continues to occur in extremely low birth weight (ELBW) infants despite formulas enriched in Ca and P. Objective This study tested whether extra enteral Ca supplementation increases bone mineral content (BMC) and prevents dolichocephalic head flattening and myopia in ELBW infants. Study design Infants 401–1000 birth weight receiving enteral feeds were randomized to receive feeds supplemented with Ca-gluconate powder, or pure standard feeds. Main outcome measures were the excretion of Ca and P by weekly spot urine measurements, the degree of dolichocephalic deformation (fronto-occipital to biparietal diameter ratio, FOD/BPD) at 36 weeks postmenstrual age and the BMC (by dual-energy x-ray absorptiometry) at discharge. Cycloplegic refraction was measured at 18–22 months corrected age. Results Ninety-nine ELBW infants with a gestational age of 26 weeks (23–31) [Median (minimum-maximum)] were randomized at a postnatal age of 12 days (5–23) weighing 790g (440–1700). Urinary Ca excretion increased, P excretion decreased in the Ca supplemented group. Total body BMC was 89.9 ± 2.4 g (mean ± SE) in the supplemented group and 85.2 ± 2.6 g in the control group (p= 0.19). The FOD/BPD was 1.50 (1.13–1.69, mean ± SD) and 1.47 (1.18–1.64) in the supplemented and control groups, and the refraction 0.98 ± 1.23 and 1.40 ± 1.33 dpt. (p=0.68), respectively in 64 ELBW infants (79% of survivors) at 2-year-follow-up. Conclusions Extra enteral Ca supplementation did not change BMC, head shape or refraction. The decreased P excretion may reflect P deficiency in infants receiving extra Ca, preventing improved bone mineral accretion.

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Section: Discussionmentioning

confidence: 99%