Untersuchungen zum Einfluß von Glycopyrrolat und Atropin auf das Verhalten der Herzfrequenz und den pH-Wert des Magensaftes während Mikrolaryngoskopien

Lischke, V.; Behne, M.; Mickel, A.

doi:10.1055/s-2007-1001627

Cited by 2 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In doses assumed to be equipoint with respect to acceleration of H R during anaesthesia (1), the two test drugs were followed by the same acceleration of H R before induction. Most previous studies reported an increase in H R by atropine only ( 7 , 12,13), but Lischke et al, studying the same doses, reported findings similar to those of the present study (14). Unfortunately, levels of significance were not stated.…”

Section: Discussioncontrasting

confidence: 46%

“…In our previous study ( 7 ) of patients under ketamine/ diazepam anaesthesia and in a study of patients having bronchoscopy under thiopentone/suxamethonium anaesthesia (16), no difference was found with respect to the occurrence of arrhythmias. However, other studies suggest that arrhythmias are more frequent after atropine than after glycopyrrolateand possibly least frequent after placebo (3, 14).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glycopyrrolate vs. atropine during anaesthesia for laryngoscopy and bronchoscopy

Grønnebech

Johansson

Smedebøl

et al. 1993

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

As glycopyrrolate has been reported superior to atropine with respect to reduction of salivation, stability of cardiac rate and rhythm, and recovery, a comparison of these properties of the two drugs and placebo was made in 45 patients undergoing direct laryngoscopy and 45 patients undergoing bronchoscopy, in most cases followed by mediastinoscopy. When given i.m. 30 min before anesthesia (midazolam, alfentanil, thiopentone, and suxamethonium), the two test drugs were found to be equally potent regarding the antisialogogic effect. The same increase in heart rate after the test drugs was seen before induction, and during anaesthesia heart rate rose to the same level in the placebo group as the test groups. During anaesthesia, blood pressure was lowest in the atropine group. No differences could be demonstrated with respect to cardiac arrhythmias, possibly due to the small size of the material. The present study gives no reason for preferring either drug, and only the efficacy of both test drugs in controlling airway secretions provides an argument for using any anticholinergic drug when laryngoscopy or bronchoscopy is performed under the conditions of the present study.

show abstract

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%