Untersuchungen zur Konfiguration von 4-Nitroimidazolnucleosiden / Investigations on the Configuration of 4-Nitro Imidazole Nucleosides

Abstract

It is demonstrated that the 220—225 nm Cotton effect of 4-nitro imidazole nucleosides can be used for the determination of the configuration of this class of compounds. A more detailed picture about conformation and configuration of the sugar residue is received from the copperammonia complexes of these nucleosides.The pH-dependency of the stability and the complex ratio are discussed for a furanose moiety. Correlation between signs and intensities of the Cotton effects and configurations and conformations of the diol structures are discussed.

Circular Dichroism Studies on New Optically Active 1,5-Benzodiazepine Derivatives

“…In continuation of our circular dichroism studies on natural products and biologically active com pounds like carbohydrates [13][14][15][16][17][18][19][20][21], nucleosides and nucleotides [22][23][24][25][26], flavone glycosides [27][28][29], amino acids, peptides and proteins [30][31][32][33][34][35][36][37][38][39][40][41][42], steroids [43,44] or benzodiazepine derivatives [9,10,45], the UV-and CD-spectroscopic properties of thirty three new chiral benzodiazepine deriva tives are discussed in this communication.…”