Untersuchungen zur Pathogenese der Lichturticaria

Solar Urticaria

“…Antimalarial agents, 5 oral ␤-carotene, 6,7 and oral steroids 4 are of little value in the treatment of solar urticaria. Antihistamines are still the therapy of first choice because histamine may be an important mediator in solar urticaria.…”

“…The urticarial response can also be decreased by cooling the corresponding areas of the skin immediately after irradiation. 4 It is more important to try to prevent whealing. The choice of the treatment and the response to the treatment will then depend mainly on 2 factors: the action spectrum to which the patient reacts and the severity of the lesions as expressed by the MUD.…”

“…Antihistamines can reduce the whealing and itching in many patients. 4,8 Especially interesting are the antihistamines of the new generation, among which the H 1 -receptor antihistamines are generally superior. 9 Many studies conducted to date have been done with terfenadine.…”

Solar urticaria: the annoying photodermatosis

“…The most frequent localizations are the V-area of the neck and the arms, 23 which are similar to the sites of a polymorphic light eruption. Solar urticaria lesions have also been reported on the tongue and lips of a patient who fell asleep in the sun with his mouth open, 30 and they can occur through window glass or when the individual uses a sunbed. 31 Exaggerated susceptibility to whealing has been reported in bruised areas of skin.…”

“…77 There are arguments that it could be β-globulin. 78 The fact that solar irradiation of the injected site has to be performed at least 2-6 h after serum injection in order to obtain an urticarial reaction 79 demonstrates that this reaction is not due to a phototoxic substance in the serum and suggests a photoallergic mechanism. Antigens induced in the serum or plasma by light irradiation become photoallergens.…”