Untersuchungen zur Regulation von CRH, ACTH und Kortisol in der Trophoblastzelle in vitro

The results suggest that CRH and ACTH directly modulate the endocrine function of trophoblasts in culture by downregulating progesterone production. Prednisolone on the other hand showed a stimulating effect on progesterone production in term trophoblast cells in vitro. Because blockade of progesterone is a possible mechanism involved in initiation of labor, we may speculate that CRH and ACTH are directly involved in the auto- or paracrine regulation of this procedure.

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Maternal serum corticotropin‐releasing hormone and ACTH levels as predictive markers of premature labor

Makrigiannakis

Semmler

Briese

et al. 2007

Intl J Gynecology & Obste

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Untersuchungen zur Regulation von CRH, ACTH und Kortisol in der Trophoblastzelle in vitro

Abstract: The trophoblast cell shows a rhythmical course in the concentration of cortisol. For the first time a CRH-ACTH-cortisol feedback loop could be demonstrated in cultured trophoblast cells.

Cited by 3 publications

References 34 publications

Glycodelin A and differentiation of first trimester trophoblast cells in vitro

Glycodelin A and differentiation of first trimester trophoblast cells in vitro

Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisolone)

Maternal serum corticotropin‐releasing hormone and ACTH levels as predictive markers of premature labor

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