Unusual Cutaneous Manifestations of Pentazocine Addiction

Schiff, Bencel L.; Kern, Arthur B.

doi:10.1001/jama.1977.03280150112045

Cited by 17 publications

(10 citation statements)

References 5 publications

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“…3). 31,[48][49][50][51][52][53][54] For example, quinine used as an adulterant has caustic effects. In addition some drugs such as cocaine have potent vasoconstrictive and thrombotic effects.…”

Section: Acute Complicationsmentioning

confidence: 99%

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Cutaneous complications of intravenous drug abuse

2004

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Injection drug abuse is a world-wide problem responsible for numerous minor to life-threatening and fatal complications. The skin is the tissue most evidently affected by intravenous drug addiction. A wide spectrum of cutaneous complications may occur in intravenous drug users. These include acute or delayed local complications, hypersensitivity reactions, cutaneous manifestations of systemic infections or becoming the site of toxigenic infections. Between 1996 and 2001, in our institution in south-eastern France, we observed cutaneous complications after crushed buprenorphine tablet injections in 13 patients. This paper reviews and classifies adverse effects of parenteral drug abuse on the skin.

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Section: Acute Complicationsmentioning

confidence: 99%

“…Pentazocine abuse was responsible for extensive ÔwoodyÕ cutaneous fibrosis. [48][49][50][51] Histopathological analysis and examination of tissues under polarized light can show the presence of birefringent material, such as starch, talc and other foreign particles. 7,82,86 Raynaud's phenomenon and peripheral ischaemia.…”

Section: Delayed Complicationsmentioning

confidence: 99%

Cutaneous complications of intravenous drug abuse

2004

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“…In some cases fibrotic contractures of muscle occur and in others there is a mixture of the cutaneous and muscle changes. These changes are usually limited to the injection sites hut have been reported in more distant areas . In several recent cases of ulceration we have employed benzoyl peroxide dressing with some success, but generally lesions are extremely slow to heal.…”

Section: Miscellaneous Conditionsmentioning

confidence: 99%

Ulcers Associated with the Swollen Leg

Taylor¹,

Young²

1978

The Journal of Dermatologic Surgery and Oncology

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A number of disparate conditions may produce ulcers in swollen legs. The most frequent causative condition is venous stasis; other causal disorders are lymphatic obstruction, mixed vascular anomalies, benign and malignant neoplasms and a number of miscellaneous conditions. Careful attention to cutaneous signs of these conditions may be helpful in arriving at an accurate diagnosis and appropriate therapy.

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“…Although rare AEs to pentazocine have not been reported in children, myofibrosis and its calcified form had been reported in adults following prolonged use of high-dose pentazocine [22,23]. Other rare AEs reported in adults include fibrosis at the injection site [24], irregular punched-out abscesses with a rim of hyper-pigmentation surrounding the ulcer [25,26], bilateral deep vein thrombosis, toxic epidermal necrolysis, generalized erythematous desquamative rash [27], fibromyositis and contracture [28].…”

Section: Introductionmentioning

confidence: 99%

Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review

Oshikoya

Ogunyinka

Godman

2019

Current Medical Research and Opinion

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Background and aims: Pentazocine remains a widely used opioid pre-anesthetic medication and postoperative analgesic in low-and middle-income countries (LMICs) despite concerns. We assessed the adverse events (AEs) associated with off-label use of pentazocine in pediatric surgical patients and determined the possible risk factors associated with slow respiratory AEs. Method: Children ≤ 18 years old for surgery administered pentazocine IM/IV as a pre-anesthetic medication or post-operative analgesic. Pertinent data including total daily dose and duration of use of pentazocine and its associated AEs were obtained from patients' case files. Risk factors associated with slow respiratory AEs were determined using logistic regression analyses. Results: 159 patients were included with median age of 2 years and mainly males (52.8%). Pentazocine was administered off-label to all patients for post-operative pain management (96.2%) or pre-anesthetic medication (3.8%). All patients experienced at least one AE with most experiencing 2-7 AEs. Rapid breathing (116; 18.4%), followed by sleepiness/sedation/drowsiness (90; 14.3%) and fast pulse (79; 12.5%) was the most frequently reported AEs. None of the demographics and clinical variables significantly predicted the risk of slow respiratory AEs. Conclusion: Off-label use of pentazocine is common and associated with multiple AEs. Care is needed as no predictors of slow respiratory AEs were observed.

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Unusual Cutaneous Manifestations of Pentazocine Addiction

Cited by 17 publications

References 5 publications

Cutaneous complications of intravenous drug abuse

Cutaneous complications of intravenous drug abuse

Ulcers Associated with the Swollen Leg

Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review

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