Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides

Geng, Hao; Yan-chun, Liu; Li, De‐Sen; Xiao, Chao‐Jiang; Liu, Yan; Li, Xiaonian; Li, Shenghong

doi:10.1016/j.phytochem.2020.112325

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Phlomoidesides A-F, six unusual glycosidic labdane diterpenoids, were isolated by methanolic extraction and subsequent partitioning in different solvents, from the root of Phlomoides betonicoides (Diels) Kamelin and Makhm (Lamiaceae), a perennial herb present in China [56]. The structures of these compounds were determined by extensive spectroscopic analyses (including 1D NMR, 2D NMR, and HRMS), single crystal X-ray diffraction, and calculated 13 C NMR.…”

Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

“…Only phlomoideside A 92 showed an IC 50 value of 7.5 µM against the MCF-7 cell line, better than the positive control cisplatin (Figure 37). [56] and hedychin B 93 [57].…”

Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

“…Their structures were achieved by comprehensively analyzing the spectroscopic data and electronic circular dichroism spectra and using X-ray crystallographic analysis. Among them, sublyratin I 95 displayed cytotoxic activity against the HL-60 cell line, with an IC50 value of 2.8 μM, using the sulforhodamine B (SRB) and cell counting kit-8 (CCK-8) assays and [56] and hedychin B 93 [57].…”

Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

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New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

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2022

Plants

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Diterpenes represent a wider class of isoprenoids, with more than 18,000 isolated compounds, and are present in plants, fungi, bacteria, and animals in both terrestrial and marine environments. Here, we report on the fully characterised structures of 251 new diterpenes, isolated from higher plants and published from 2017, which are shown to have antitumoral activity. An overview on the most active compounds, showing IC50 < 20 μM, is provided for diterpenes of different classes. The most active compounds were extracted from 29 different plant families; particularly, Euphorbiaceae (69 compounds) and Lamiaceae (54 compounds) were the richest sources of active compounds. A better activity than the positive control was obtained with 33 compounds against the A549 cell line, 28 compounds against the MCF-7 cell line, 9 compounds against the HepG2 cell line, 8 compounds against the Hep3B cell line, 19 compounds against the SMMC-7721 cell line, 9 compounds against the HL-60 cell line, 24 compounds against the SW480 cell line, and 19 compounds against HeLa.

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Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

“…Only phlomoideside A 92 showed an IC 50 value of 7.5 µM against the MCF-7 cell line, better than the positive control cisplatin (Figure 37). [56] and hedychin B 93 [57].…”

Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

Section: Labdane-type Diterpenoidsmentioning

confidence: 99%

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New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

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Nitti

2022

Plants

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Tropane alkaloids from the stem bark of Erythroxylum bezerrae

et al. 2020

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Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge

Usmanov

Azamatov

Baykuziyev

et al. 2022

Natural Product Research

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An analysis method was developed for the separation and quantification of hesperidin, neohesperidin, neohesperidin dihydrochalcone and hesperetin by using HPLC-UV. Single factor experiments and Box-Behnken Designs were used to optimize separation of four flavonoids, in which a gradient elution method was adopted with 99% acetonitrile and 0.1% formic acid as mobile phases at a flow rate of 0.9 mL/min. A C18 column was used with a column temperature of 35℃. LODs and LOQs were below 0.84 µg/mL and 2.84 µg/mL, respectively. Linearity with good correlation coefficients (r>0.99, n=5) was attained, recovery rate of four flavonoids ranged from 88% to 130%, the RSD indicating results precision for analyzing hesperidin, neohesperidin, neohesperidin dihydrochalcone and hesperetin ranged from 1.2% to 4.6%. Finally, the 2 present method could be successfully applied to identify and quantify hesperidin, neohesperidin and hesperetin in Fructus Aurantii Immaturus and Pericarpium Citri Reticulatae.

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Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides

Cited by 3 publications

References 18 publications

New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

Tropane alkaloids from the stem bark of Erythroxylum bezerrae

Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge

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