Unusual metastasis of esophageal cancer

Vidović, Vitomir; Nikolić, Ivan; Vukojevic, Jelena; Samardzija, Golub; Kukić, Biljana; Bogdanovic, Bogdan; Petrovic, Nemanja

doi:10.2298/vsp1410975v

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Metastatic lesions have been recorded as presenting on the skin of the limbs, back and abdominal wall [ 5 , 7 , 8 ]. Lesions in the head and neck have presented in the skin of the lip, frontal and temporal regions and the scalp [ 5 , 9 , 10 ]. The incidence of oesophageal carcinoma is rising [ 4 ], and it has been proposed that this, alongside improvements in management could lead to cutaneous metastasis becoming more common.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek

Higgins

Monaghan

Mani

2017

Journal of Surgical Case Reports

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This case report details of a case of cutaneous metastasis from a primary adenocarcinoma of the oesophagus to the right cheek. A 67-year-old male was referred to the maxillofacial department with a 2–3 week history of non-painful swelling of the cheek. A diagnosis of infected sebaceous cyst was made and drainage was attempted with adjunctive antibiotic therapy. Follow up appointments showed no improvement a biopsy was taken. Histology reported presence of metastatic adenocarcinoma, suggesting the gastrointestinal tract as the primary site. An MRI scan was performed showing an oesophageal mass. Treatment options were discussed with the patient, including surgery, radiotherapy and chemotherapy. Unfortunately, the advanced nature of the primary lesion meant his care was mainly palliative in nature. Clinicians must have a high index of suspicion regarding non-healing cutaneous lesions. Timely investigations in the will help to diagnose the primary cause of the lesion.

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Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek

Higgins

Monaghan

Mani

2017

Journal of Surgical Case Reports

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“…Lips are a complex anatomical structure with a significant functional and aesthetic role which can be affect by numerous pathologies with different etiology [1]. Furthermore, lips often reveal to be the first site of manifestation of important systemic diseases [2]. This emphasizes the role of the dentist in the early detection of these disorders.…”

Section: Introductionmentioning

confidence: 99%

Labial Lesion with Heterogeneous Aspects in a Patient with Chronic Renal Failure: Diagnostic Difficulties and Literature Review

Murgia

Orrù

Viganò

et al. 2019

The XV National and III International Congress of the Italian Society of Oral Pathology and Medicine

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“…In China, it ranks fourth (2) in incidence among all cancers and its major pathohistological subtype is esophageal squamous cell carcinoma (ESCC). The majority of esophageal cancer patients hospitalized are often diagnosed with advanced ESCC that metastasizes to local lymph nodes (3,4). Thus, the outcomes and prognosis of patients with ESCC are poor (5), despite the improvements in therapy (6), with the 5-year survival rate being no more than 15% (7).…”

Section: Introductionmentioning

confidence: 99%

KIAA1377 is associated with lymph node metastasis in esophageal squamous cell carcinoma

Yang

Liu

et al. 2016

Oncology Letters

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Abstract. KIAA1377, of which there are few studies regarding cell biology and neurological diseases, has been found to be significantly amplified in esophageal squamous cell carcinoma (ESCC) with lymph node metastasis compared with ESCC without lymph node metastasis. This suggests that KIAA1377 may play a role in the lymph node metastasis of ESCC. There has, to the best of our knowledge, been no study performed to investigate the role of KIAA1377 in ESCC. In the present study, the expression of KIAA1377 was detected by immunohistochemistry, and its expression was statistically analyzed with clinicopathological parameters, using commercially obtained tissue arrays consisting of 86 cases of ESCC and 79 paired controls. KIAA1377 was knocked down ex vivo using transient transfection with specific small hairpin RNA (shRNA) vectors into ESCC TE-1 and EC9706 cell lines whose endogenous KIAA1377 level was highest. The variation of proliferation, migration and invasion were evaluated using methyl thiazolyl tetrazolium, wound healing and Transwell assay, respectively. It was found in vivo that KIAA1377 expression was significantly associated with lymph node metastasis and differentiation, and ex vivo that knockdown of KIAA1377 cannot significantly affect proliferation and mobility in the ESCC cell line TE-1. Overall, this is the first study suggesting that KIAA1377 may play a role in the lymph node micrometastasis of ESCC.

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Unusual metastasis of esophageal cancer

Abstract: The physicians should always consider unusual skin lesions as the first sign of cancer spreading.

Cited by 6 publications

References 9 publications

Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek

Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek

Labial Lesion with Heterogeneous Aspects in a Patient with Chronic Renal Failure: Diagnostic Difficulties and Literature Review

KIAA1377 is associated with lymph node metastasis in esophageal squamous cell carcinoma

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