Unusual Presentations of Pediatric Neurobrucellosis

Budnik, Isolda; Fuchs, Inbal; Shelef, Ilan; Krymko, Hana; Greenberg, David

doi:10.4269/ajtmh.2012.11-0468

Cited by 16 publications

(10 citation statements)

References 12 publications

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“…Neuroimaging reveals inflammatory changes and raised intracranial pressure with ventricular dilatation or rarely as a space-occupying lesion. 8 Hematological findings in brucellosis are reported to be either normal or include anemia, leukopenia, neutropenia, thrombocytopenia, and pancytopenia. 9 Treatment of brucellosis is preferred to be started in combination therapy in order to avoid relapse.…”

Section: Discussionmentioning

confidence: 99%

Brucellosis: A Case Report and Literature Review

Hakeem¹,

Saeed²

2019

Journal of Postgraduate Medicine, Education and Research

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Brucellosis is a major cause of febrile illnesses in areas with high exposure to animals or unpasteurized milk and dairy products. It may manifest with multisystem clinical presentations. Our patient was a six-year-old boy who was presented in emergency room with a prolonged history (3 weeks) of high-grade fever with chills, not responding to antibiotics. Upon inquiry, the history revealed the use of unpasteurized goat milk and contact with goats at home. Upon investigation, serum antibodies for brucellosis were raised (1:640). He was started on combination therapy with rifampicin and doxycycline. He became afebrile within two days so was discharged home. We found that an ineffective history could lead to delay in diagnosis and management. Clinicians should have high index of suspicion for brucellosis in children.

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Section: Discussionmentioning

confidence: 99%

Brucellosis: A Case Report and Literature Review

Hakeem¹,

Saeed²

2019

Journal of Postgraduate Medicine, Education and Research

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“…CSF PCR for Brucella has been proposed for diagnosis and follow up (Pappas et al, 2007), however, it was repeatedly negative in our case. Based on recent reports of 16s rRNA use in neurobrucellosis, albeit with mixed results (Budnik et al, 2012, Renard et al, 2006, Valenza et al, 2006, we used CSF from the initial puncture for 16s rRNA sequencing, which finally allowed us to verify the presence of Brucella spp in the CNS. To the best of our knowledge, this is the first reported case in which the use of CSF 16s rRNA sequencing aided in the diagnosis of seronegative, CSF culture-negative neurobrucellosis.…”

Section: Discussionmentioning

confidence: 99%

Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?

Papadopoulos

Patas

Tountopoulou

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Neurobrucellosis has neither typical clinical manifestations nor special manifestations in CSF. Its discovery of neurobrucellosis is based on the existence of nervous system manifestations not explained by any other neurological disease, which may lead to a delay in the diagnosis of neurobrucellosis [ 13 , 14 ]. In the case presented here, the patient had cerebrovascular accidents as the primary symptom and did not have a high risk factor for brucellosis; therefore, brucelosis was not considered in the initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Subarachnoid hemorrhage secondary to Brucella-induced cerebral aneurysm: a case report

Yanyan

Yao

et al. 2021

BMC Infect Dis

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Background Brucellosis is a common zoonotic disease that is prevalent in many areas worldwide. This infectious disease can occasionally affect the central nervous system but intracranial arteries are rarely involved. Case presentation A 17-year-old female who had a history of recurrent fever for 1 month was admitted for subarachnoid hemorrhage due to cerebral aneurysm rupture. Surgery was performed to fix the aneurysm, but the patient had persistent fever after the surgery. Cerebrospinal fluid testing showed a high white blood cell count and elevated protein level but no pathogen was identified in the first two tests. Brucella melitensis was identified in the third cerebrospinal fluid culture, and a diagnosis of brucellosis was finally rendered. The patient was subsequently treated with anti-Brucella medications and her symptoms improved significantly at the last follow-up. Conclusion Although extremely rare, Brucella-induced cerebral aneurysms can occur and this should be considered in the differential diagnosis of cerebrovascular accidents, especially in Brucella epidemic areas.

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Unusual Presentations of Pediatric Neurobrucellosis

Cited by 16 publications

References 12 publications

Brucellosis: A Case Report and Literature Review

Brucellosis: A Case Report and Literature Review

Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?

Subarachnoid hemorrhage secondary to Brucella-induced cerebral aneurysm: a case report

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